Application Progress of Prussian Blue Nanoparticles in Cancer Therapy and Imaging
ZHANG Xueyan1,2, MENG Zhaoxu1, LIAN He1
1 School of Medical Devices, Shenyang Pharmaceutical University, Benxi 117004, China 2 School of Pharmacy, Shenyang Pharmaceutical University, Benxi 117004, China
Abstract: Based on the pursuit of human health, aiming at improving the patients’ living standard, searching for better cancer treatments has always been the hot topic of research around the world. With the development of nanotechnology, more and more nanomaterials are used in tumor therapy. Photothermal therapy is a newly developed method in recent years which uses photothermal nanomaterials to destroy tumor cells with non-invasive management. Prussian blue is a coordination compound, and it has been approved by the FDA for the clinical treatment with reliable biological safety. Prussian blue nanoparticles has stable chemical properties, controllable shape and size sufficient synthetic raw materials and simple synthetic method. With good photothermal properties, it has been developed as a photothermal conversion agent. Prussian blue can also be used as a contrast agent in MRI, PA and ultrasound imaging, which opens up a new prospect for the tumor diagnosis and treatment. In this paper, we will introduce the application of prussian blue nanoparticles in cancer therapy from the aspects of photothermal therapy, tumor imaging and so on.
作者简介: 张雪雁,毕业于沈阳药科大学,于2020年7月获得理学学士学位,研究方向为新型生物医用材料。孟昭旭,沈阳药科大学副教授。2011年毕业于哈尔滨工程大学,获材料学博士学位,毕业后赴中科院大连化学物理研究所进行博士后研究。2013年入职沈阳药科大学。获得“辽宁省百千万人才万人层次”和“沈阳市拔尖人才”荣誉称号。研究方向主要有生物医用材料、组织修复与再生材料及新型医疗器械研究。作为课题负责人主持了国家自然科学基金青年基金项目1项,辽宁省教育厅项目2项,沈阳市科技计划项目1项,沈阳药科大学中青年发展支持计划基金1项。目前已在Mat. Sci. Eng C, J. Mater. Sci, Materials & Design, Colloids Surf. B, Small, Nanocsale等期刊发表论文20余篇。廉鹤,2014年获得沈阳药科大学药剂学博士学位,现为医疗器械学院生物医用材料教研室副教授。研究方向为生物材料和新型纳米药物递送系统。作为课题负责人主持国家自然科学基金项目1项,辽宁省自然科学基金1项,辽宁省教育厅项目1项,沈阳药科大学科研专项基金1项,另外参与国家自然科学基金4项。目前已在Mat. Sci. Eng C, J. Contrl. Res,Mol. Pharm, Colloids Surf. B, Biomaterial Science, Macromol. Biosci.等期刊发表论文20余篇,获得授权专利2项。
引用本文:
张雪雁, 孟昭旭, 廉鹤. 普鲁士蓝基纳米粒子在癌症治疗及成像中的应用进展[J]. 材料导报, 2020, 34(Z2): 95-98.
ZHANG Xueyan, MENG Zhaoxu, LIAN He. Application Progress of Prussian Blue Nanoparticles in Cancer Therapy and Imaging. Materials Reports, 2020, 34(Z2): 95-98.
1 周亚丹, 朱江. 中华超声影像学杂志, 2019(8), 733. 2 郭一霏. 多孔磁性普鲁士蓝复合材料的合成研究. 硕士学位论文, 华东师范大学, 2017. 3 Gautam M, Poudel K, Yong C S, et al. International Journal of Pharmaceutics, 2018,549(1-2),31. 4 Fu G L, Liu W, Feng S S, et al. Chemical Communications, 2012, 48(94), 11567. 5 Yao J, Wang L V. Current Opinion in Chemical Biology, 2018, 45,104. 6 Yan L, Zhou X, Zheng Y, et al. Clinics, 2019, 74,e715. 7 Liu J, Pan Y, Li M, et al. Big Data Mining and Analytics, 2018, 1(1), 1. 8 Houbois C P, Thavendiranathan P, Wintersperger B J, et al. Journal of Thoracic Imaging, 2020, 35(1), 12. 9 Yang K, Feng L Z, Liu Z, et al. Advanced Drug Delivery Reviews, 2016, 105, 228. 10 Wu J, Williams G R, Niu S, et al. Theranostics, 2020, 10(2), 841. 11 Su Y Y, Yao H, Zhao S, et al. Journal of Colloid and Interface Science, 2018, 512, 439. 12 Zhang L, Zhang Y, Xue Y N, et al. Advanced Materials, 2019, 31, 8. 13 Lei Y T, Zeng L, Xie S Q, et al. Chemical Biology & Drug Design, 2020, 95(3), 320. 14 Xu W J, Qian J M, Hou G H, et al. Acta Biomaterials, 2019, 83, 400. 15 Ming J, Zhang J J, Shi Y R, et al. Nanoscale, 2020, 12(6), 3916. 16 刘迪. 光热治疗联合免疫治疗复合制剂抗肿瘤活性研究. 硕士学位论文,苏州大学, 2016. 17 陈华健. 肿瘤热化疗用普鲁士蓝纳米载药颗粒的构建及性能表征. 硕士学位论文,合肥工业大学, 2018. 18 Arindam Bhattacharjee, áron Szabó, Tamás Csizmadia, et al. Journal of Genetics and Genomics, 2019, 46(4), 157. 19 Liu B, Wang W M, Fan J L, et al. Biomaterials, 2019,217,119301. 20 Liang X L, Deng Z J, Jing L J,et al. Chemical Communications, 2013, 49(94), 11029. 21 Tian W, Su Y Y, Tian Y, et al. Advanced Science, 2017, 4(3). 22 Yang F, Hu S L, Zhang Y, et al. Advanced Materials, 2012, 24(38), 5205. 23 徐燕军. 普鲁士蓝纳米粒的设计合成及在肿瘤多模式显像和热疗中的应用. 博士学位论文, 上海交通大学, 2018. 24 Feng S S, Wang J, Liang X, et al. Journal of Nanoscience and Nanotechnology, 2016, 16(3), 2184. 25 Shokouhimehr M, Soehnlen E S, Khitrin A, et al. Inorganic Chemistry Communications, 2010, 13(1), 58. 26 Li Z Z, Zeng Y Y, Zhang D, et al. Journal of Materials Chemistry B, 2014, 2(23), 3686. 27 Liu Y X, Guo Q W, Zhu X, et al. Advanced Functional Materials, 2016, 26(28), 5120. 28 Zhang N, Cai X J, Gao W, et al. Theranostics, 2016, 6(3), 404. 29 康宝江. 基于普鲁士蓝多功能纳米粒子的制备及其应用研究. 硕士学位论文, 长春理工大学, 2019. 30 Li J H, Zhang F S, Hu Z G, et al. Advanced Healthcare Materials, 2017, 6(14), 170005. 31 Kim H, Chung K, Lee S J, et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2016, 8(1), 23. 32 Kue C S, Kamkaew A, Burgess K, et al. Medicinal Research Reviews, 2016, 36(3), 494. 33 尚婷婷. 载普鲁士蓝靶向纳米复合物多模态显像及综合治疗裸鼠乳腺癌的实验研究.博士学位论文, 重庆医科大学, 2017. 34 Jing L J, Shao S M, Wang Y, et al. Theranostics, 2016, 6(1), 40. 35 Mottaghitalab F, Farokhi M, Fatahi Y, et al. Journal of Controlled Release, 2019, 295, 250. 36 Dou Y, Li X, Yang W T, et al. ACS Applied Materials & Interfaces, 2017, 9(2), 1263.
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2020, Vol. 34 
