葡萄糖响应涂层修饰的聚醚醚酮用于糖尿病骨缺损的抗菌治疗研究

doi:10.11896/cldb.24030239

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Abstract The characteristics of high glucose concentration and low pH value in the wound microenvironment of diabetic patients make them vulnerable to the invasion of pathogens, dysfunction of bone cells and the induction of osteoclasts, which extremely affects the repair efficacy of implantation surgery. Presently, polyetheretherketone (PEEK) has become a promising bone implant. But its poor antibacterial ability, poor osteogenic capability and unable to respond to the microenvironment of diabetes restrictes the further application. To reverse such defects, a glucose response coating composed of copper (Cu) chelated polydopamine (PDA) metal polyphenol network (Cu/MPN) and glucose oxidase (GOx) was constructed on the surface of PEEK. After analyzing the surface morphology, chemical composition, Zeta potential and water contact angle of the modified implants, the loading capacities of GOx, temperature curves under NIR and abilities to produce H₂O₂ and ·OH in vitro were further verified. Finally, antibacterial and biosafety tests were conducted. The results indicated that we successfully constructed Cu/MPN@GOx coating on the PEEK surface, and it can produce H₂O₂ and further react to ·OH when glucose exists. The coating had significant antibacterial effects on S.aureus and E.coli in high sugar microenvironment and it did not exhibit cytotoxicity. In conclusion, the new strategy of glucose sensitive antibacterial and osteogenic coating modification proposed in this study has laid an experimental foundation for the treatment of intractable diabetic bone defects.

Key words： polyetheretherketone (PEEK) diabetes glucose oxidase (GOx) implant infection antibacterial

Published: 25 June 2025 Online: 2025-06-19

CLC number:

TB34

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	Articles by authors
	XIE Kenan
	HE Yujia
	ZHANG Qi
	XIE Lu
	HE Wenxuan

Cite this article:

XIE Kenan,HE Yujia,ZHANG Qi, et al. PEEK with Glucose Responsive Coating for Diabetic Bone Defects Antibiotic Therapy[J]. Materials Reports, 2025, 39(12): 24030239-7.

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https://www.mater-rep.com/EN/10.11896/cldb.24030239 OR https://www.mater-rep.com/EN/Y2025/V39/I12/24030239

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