刺激响应型基因递送系统在癌症治疗中的应用

doi:10.11896/cldb.24050084

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Abstract Over the past decades, there has been tremendous progress in cancer gene therapy, but adverse events such as lower gene delivery efficiency and bioavailability remain major clinical challenges. Nano-delivery systems have unique advantages in cancer therapy. Due to avoiding premature drug leakage, improving blood circulation stability, increasing drug concentration in the lesion, improving drug bioavailability, and mitigating adverse reactions of anticancer drugs, stimulus-responsive gene delivery systems have become a research hotspot in cancer therapy. In this paper, the latest research progress of stimuli-responsive gene delivery systems in the field of tumor therapy over the last years is detailed, with emphasis on endogenous stimuli (pH, enzyme, redox, reactive oxygen species, and others) and exogenous stimuli (magnetic field, heat, light, and ultrasound), respectively. The problems and challenges faced by them are discussed.

Key words： stimulius-responsive nanosystem gene delivery drug release cancer

Published: 10 May 2025 Online: 2025-04-28

CLC number:

R73-34

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	Articles by authors
	ZHANG Lihua
	LI Jiang
	WANG Juan
	YAN Xu
	WANG Junli
	BAI Yunfeng
	FENG Feng

Cite this article:

ZHANG Lihua,LI Jiang,WANG Juan, et al. Advances in Stimulus-Responsive Gene Delivery Systems in Cancer Therapy[J]. Materials Reports, 2025, 39(9): 24050084-13.

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https://www.mater-rep.com/EN/10.11896/cldb.24050084 OR https://www.mater-rep.com/EN/Y2025/V39/I9/24050084

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