刺激响应性聚氨基酸材料的设计与应用

doi:10.11896/cldb.24080169

Abstract
Figure/Table
References
Related Citation (7)

Download:

Full Text ( PDF ) (17926KB)
Export: BibTeX | EndNote (RIS)

Abstract Polypeptide materials, obtained by ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs), are an important class of biomedical materials. Through the design of functional monomers and post-polymerization modifications, polypeptide materials are able to respond to endogenous or exogenous stimuli through structural changes under specific microenvironment, thus selectively releasing the conjugated or encapsulated drugs on demand. Therefore, stimulus-responsive polypeptide materials have a wide range of studies in various biomedical fields such as drug delivery, tissue engineering, immune regulation, and antibacterial applications. Researchers have devoted numerous efforts to the design of stimulus-responsive polypeptide materials for the treatment of cancer and other diseases, aiming to enable versatile structural changes to specific stimuli. Herein we reviewed the development of stimulus-responsive chemistry in polypeptides, summarized the versatile designs of polypeptide-based nanomedicines, and highlighted their biomedical applications. The comments on the future development of stimulus-responsive polypeptides were incorporated at the end of our review.

Key words： polypeptides amino acid N-carboxyanhydrides stimulus responsiveness biomedical application

Published: 10 March 2025 Online: 2025-03-18

CLC number:

TB34

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Wanying
	LI Ning
	SONG Ziyuan

Cite this article:

WANG Wanying,LI Ning,SONG Ziyuan. Design and Application of Stimulus-responsive Polypeptide Materials[J]. Materials Reports, 2025, 39(5): 24080169-13.

URL:

https://www.mater-rep.com/EN/10.11896/cldb.24080169 OR https://www.mater-rep.com/EN/Y2025/V39/I5/24080169

1 Song Z, Han Z, Lv S, et al. Chemical Society Reviews, 2017, 46, 6570.
2 Cabral H, Miyata K, Osada K, et al. Chemical Reviews, 2018, 118, 6844.
3 Jiang Z, Liu Y, Feng X, et al. Journal of Functional Polymers, 2019, 32(1), 13 (in Chinese).
姜中雨, 刘仪轩, 冯祥汝, 等. 功能高分子学报, 2019, 32(1), 13.
4 Rasines M A, Allison-Logan S, Karimi F, et al. Chemical Society Reviews, 2020, 49, 4737.
5 Melnyk T, Dordevi S, Conejos-Sánchez I, et al. Advanced Drug Delivery Reviews, 2020, 160, 136.
6 Liu Y, Yin L. Advanced Drug Delivery Reviews, 2021, 171, 139.
7 Zhang P, Li M, Xiao C, et al. Chemical Communications, 2021, 57, 9489.
8 Zhang Y, He P, Zhang P, et al. Advanced Healthcare Materials, 2021, 10, 2001974.
9 Jiang Y, Chen Y, Song Z, et al. Advanced Drug Delivery Reviews, 2021, 170, 261.
10 Yang F, Song Z, Yin L, et al. Materials Reports, 2022, 36(3), 18 (in Chinese).
杨方平, 宋子元, 殷黎晨, 等. 材料导报, 2022, 36(3), 18.
11 Wu Y, Chen K, Wang J, et al. Progress in Polymer Science, 2023, 141, 101679.
12 Li N, Lei Y, Song Z, et al. Current Opinion in Solid State and Materials Science, 2023, 27, 101104.
13 Wu Y, Chen K, Wang J, et al. Journal of the American Chemical Society, 2024, 146, 24189.
14 Baumgartner R, Fu H, Song Z, et al. Nature Chemistry, 2017, 9, 614.
15 Wu Y, Zhang D, Ma P, et al. Nature Communications, 2018, 9, 5297.
16 Song Z, Fu H, Wang J, et al. Proceedings of the National Academy of Sciences, 2019, 116, 10658.
17 Xia Y, Song Z, Tan Z, et al. Nature Communications, 2021, 12, 732.
18 Tian Z Y, Zhang Z, Wang S, et al. Nature Communications, 2021, 12, 5810.
19 Wang W, Fu H, Lin Y, et al. Accounts of Materials Research, 2023, 4, 604.
20 Liu X, Huang J, Wang J, et al. CCS Chemistry, DOI:10.31635/ccschem.024.202403954.
21 Ji G, Zheng X, Hou X, et al. Chinese Chemical Letters, 2024, 35, 108872.
22 Sun X, Li A, Li N, et al. Biomacromolecules, 2024, 25, 6093.
23 Li N, Xiao S, Jin X, et al. Chinese Journal of Chemistry, 2024, 42, 1209.
24 Xia J, Wang W, Jin X, et al. Biomaterials Science, 2024, 12, 3896.
25 Stuart M A C, Huck W T S, Genzer J, et al. Nature Materials, 2010, 9, 101.
26 Mura S, Nicolas J, Couvreur P. Nature Materials, 2013, 12, 991.
27 Langton M J. Nature Reviews Chemistry, 2021, 5, 46.
28 Ma P, Wang Q, Luo X, et al. Biomaterials Science, 2023, 11, 5078.
29 Guerassimoff L, Ferrere M, Bossion A, et al. Chemical Society Reviews, 2024, 53, 6511.
30 Liu Y, Li C, Yang X, et al. Biomaterials Science, 2024, 12, 3805.
31 Huang J, Heise A. Chemical Society Reviews, 2013, 42, 7373.
32 Shen Y, Fu X, Fu W, et al. Chemical Society Reviews, 2015, 44, 612.
33 Wang X, Song Z, Wei S, et al. Biomaterials, 2021, 275, 120913.
34 Deming T J. Chemical Reviews, 2016, 116, 786.
35 Kramer J R, Deming T J. Journal of the American Chemical Society, 2012, 134, 4112.
36 Liu H, Wang R, Wei J, et al. Journal of the American Chemical Society, 2018, 140, 6604.
37 Zheng Y, Wang Z, Li Z, et al. Angewandte Chemie International Edition, 2021, 60, 22529.
38 Zheng Y, Liu Y, Wu Z, et al. Advanced Materials, 2023, 35, 2210986.
39 Rodriguez A R, Kramer J R, Deming T J. Biomacromolecules, 2013, 14, 3610.
40 Wu G, Ge C, Liu X, et al. Chemical Communications, 2019, 55, 7860.
41 Yao Q, Wu G, Hao H, et al. Biomacromolecules, 2021, 22, 2563.
42 Wu G, Zhou H, Zhang J, et al. Nature Synthesis, 2023, 2, 515.
43 Sulistio A, Lowenthal J, Blencowe A, et al. Biomacromolecules, 2011, 12, 3469.
44 Sulistio A, Blencowe A, Widjaya A, et al. Polymer Chemistry, 2012, 3, 224.
45 Yang J, Zou H, Ding J, et al. Acta Polymerica Sinica, 2021, 52(8), 960 (in Chinese).
杨佳臻, 邹昊洋, 丁建勋, 等. 高分子学报, 2021, 52(8), 960.
46 Sun Y, Hou Y, Zhou X, et al. ACS Macro Letters, 2015, 4, 1000.
47 Chen C, Wang Z, Li Z. Biomacromolecules, 2011, 12, 2859.
48 Yan L, Yang L, He H, et al. Polymer Chemistry, 2012, 3, 1300.
49 Liu G, Dong C M. Biomacromolecules, 2012, 13, 1573.
50 Yin L, Tang H, Kim K H, et al. Angewandte Chemie International Edition, 2013, 52, 9182.
51 Song Z, Kim H, Ba X, et al. Soft Matter, 2015, 11, 4091.
52 Xiong W, Fu X, Wan Y, et al. Polymer Chemistry, 2016, 7, 6375.
53 Bellomo E G, Wyrsta M D, Pakstis L, et al. Nature Materials, 2004, 3, 244.
54 Rodríguez-Hernández J, Lecommandoux S. Journal of the American Chemical Society, 2005, 127, 2026.
55 Krannig K S, Schlaad H. Journal of the American Chemical Society, 2012, 134, 18542.
56 Chen J, Ding J, Zhang Y, et al. Polymer Chemistry, 2015, 6, 397.
57 Du J Z, Li H J, Wang J. Accounts of Chemical Research, 2018, 51, 2848.
58 Engler A C, Bonner D K, Buss H G, et al. Soft Matter, 2011, 7, 5627.
59 Song Z, Mansbach R A, He H, et al. Nature Communications, 2017, 8, 92.
60 Bae Y, Nishiyama N, Fukushima S, et al. Bioconjugate Chemistry, 2005, 16, 122.
61 Quader S, Liu X, Toh K, et al. Biomaterials, 2021, 267, 120463.
62 Wong S, Kemp J A, Shim M S, et al. Biomaterials Science, 2020, 8, 6718.
63 Xie J, Zhao X, Zhang P, et al. Advanced Science, 2023, 10, 2204866.
64 Wang R, Yin B, Guo Y, et al. ACS Applied Polymer Materials, 2024, 6, 11653.
65 Lv S, Wu Y, Cai K, et al. Journal of the American Chemical Society, 2018, 140, 1235.
66 Xiong M, Han Z, Song Z, et al. Angewandte Chemie International Edition, 2017, 56, 10826.
67 Ge C, Zhu J, Ye H, et al. Journal of the American Chemical Society, 2023, 145, 11206.
68 Ge C, He J, Gan M, et al. Biomacromolecules, 2024, 25, 3373.
69 Cheng Y, He C, Xiao C, et al. Polymer Chemistry, 2011, 2, 2627.
70 Chopko C M, Lowden E L, Engler A C, et al. ACS Macro Letters, 2012, 1, 727.
71 Jing X, Zhu Z, Wang S, et al. Biomacromolecules, 2024, 25, 5343.
72 Kotharangannagari V K, Sánchez-Ferrer A, Ruokolainen J, et al. Macromolecules, 2011, 44, 4569.
73 Kumar S, Allard J F, Morris D, et al. Journal of Materials Chemistry, 2012, 22, 7252.
74 Ding J, Zhuang X, Xiao C, et al. Journal of Materials Chemistry, 2011, 21, 11383.
75 Wang K, Luo G F, Liu Y, et al. Polymer Chemistry, 2012, 3, 1084.
76 Tai W, Mo R, Di J, et al. Biomacromolecules, 2014, 15, 3495.
77 Deepagan V G, Kwon S, You D G, et al. Biomaterials, 2016, 103, 56.
78 Yu J, Qian C, Zhang Y, et al. Nano Letters, 2017, 17, 733.
79 Hu X, Yu J, Qian C, et al. ACS Nano, 2017, 11, 613.
80 Zhang P, Yang H, Shen W, et al. ACS Biomaterials Science & Engineering, 2020, 6, 2167.
81 Qian C, Feng P, Yu J C, et al. Angewandte Chemie International Edition, 2017, 56, 2588.
82 Xu Q, He C, Ren K, et al. Advanced Healthcare Materials, 2016, 5, 1979.
83 Yu S, Wang C, Yu J, et al. Advanced Materials, 2018, 30, 1801527.
84 Negri G E, Deming T J. ACS Macro Letters, 2016, 5, 1253.
85 Ji S, Xu L, Fu X, et al. Macromolecules, 2019, 52, 4686.
86 Zhao L, Ding J, Xiao C, et al. Journal of Materials Chemistry, 2012, 22, 12319.
87 Naito M, Ishii T, Matsumoto A, et al. Angewandte Chemie International Edition, 2012, 51, 10751.
88 Fu X, Ma Y, Shen Y, et al. Biomacromolecules, 2014, 15, 1055.
89 Li S L, Hou Y, Hu Y, et al. Biomaterials Science, 2017, 5, 1558.
90 Lee Y, Miyata K, Oba M, et al. Angewandte Chemie International Edition, 2008, 47, 5163.
91 Chen P, Qiu M, Deng C, et al. Biomacromolecules, 2015, 16, 1322.
92 Chen Y, Pang X H, Dong C M. Advanced Functional Materials, 2010, 20, 579.
93 Chen L, Hong Y, He S, et al. Acta Physico-Chimica Sinica, 2021, 37, 1910059.
94 Tian H, Guo Z, Lin L, et al. Journal of Controlled Release, 2014, 174, 117.
95 Chen J, Dong X, Feng T, et al. Acta Biomaterialia, 2015, 26, 45.
96 Miyata K, Oba M, Nakanishi M, et al. Journal of the American Chemical Society, 2008, 130, 16287.
97 Zhou Y, Liang Q, Wu X, et al. Advanced Materials, 2023, 35, 2210691.
98 Zhu J, Li X, Zhou Y, et al. Science Advances, 2024, 10, eabd7904.
99 Ye H, Yan J, Ge C, et al. Chemical Engineering Journal (Lausanne), 2024, 483, 149093.
100 Lee Y, Ishii T, Cabral H, et al. Angewandte Chemie International Edition, 2009, 48, 5309.
101 Thambi T, Son S, Lee D S, et al. Acta Biomaterialia, 2016, 29, 261.
102 Kinoh H, Miura Y, Chida T, et al. ACS Nano, 2016, 10, 5643.
103 Xue S, Gu X, Zhang J, et al. Biomacromolecules, 2018, 19, 3586.
104 Lv S, Tang Z, Song W, et al. Small, 2017, 13, 1600954.
105 Li M, Song W, Tang Z, et al. ACS Applied Materials & Interfaces, 2013, 5, 1781.
106 Lv S, Li M, Tang Z, et al. Acta Biomaterialia, 2013, 9, 9330.
107 Yu S, Zhang D, He C, et al. Biomacromolecules, 2017, 18, 4341.
108 Chida T, Miura Y, Cabral H, et al. Journal of Controlled Release, 2018, 292, 130.
109 Mochida Y, Cabral H, Miura Y, et al. ACS Nano, 2014, 8, 6724.
110 Kukula H, Schlaad H, Antonietti M, et al. Journal of the American Chemical Society, 2002, 124, 1658.
111 Rodríguez-Hernández J, Lecommandoux S. Journal of the American Chemical Society, 2005, 127, 2026.
112 Koo A N, Min K H, Lee H J, et al. Biomaterials, 2012, 33, 1489.
113 Fan J, Zou J, He X, et al. Chemical Science, 2014, 5, 141.
114 Chang X, Liu L, Guan Y, et al. Journal of Polymer Science Part A:Po-lymer Chemistry, 2014, 52, 2000.
115 Ding J, Chen J, Li D, et al. Journal of Materials Chemistry B, 2013, 1, 69.
116 Takae S, Miyata K, Oba M, et al. Journal of the American Chemical Society, 2008, 130, 6001.
117 Zhao L, Xiao C, Ding J, et al. Polymer Chemistry, 2015, 6, 3807.
118 Zhang Y, Ding J, Li M, et al. ACS Applied Materials & Interfaces, 2016, 8, 10673.
119 Chen J, Ding J, Xu W, et al. Nano Letters, 2017, 17, 4526.
120 Zhang P, Zhang Y, Ding X, et al. Advanced Materials, 2020, 32, 2000013.
121 Miyata K, Kakizawa Y, Nishiyama N, et al. Journal of the American Chemical Society, 2004, 126, 2355.
122 Dai J, Lin S, Cheng D, et al. Angewandte Chemie International Edition, 2011, 50, 9404.
123 Wu L, Zou Y, Deng C, et al. Biomaterials, 2013, 34, 5262.
124 Huang K, Shi B, Xu W, et al. Acta Biomaterialia, 2015, 27, 179.
125 Guo H, Xu W, Chen J, et al. Journal of Controlled Release, 2017, 259, 136.
126 Chen J, Ding J, Wang Y, et al. Advanced Materials, 2017, 29, 1701170.
127 Xiong M, Bao Y, Xu X, et al. Proceedings of the National Academy of Sciences, 2017, 114, 12675.