磁性水凝胶作为药物载体的应用研究进展<sup>*</sup>

doi:10.11896/j.issn.1005-023X.2017.015.005

Abstract
Figure/Table
References
Related Citation (15)

Download:

Full Text ( PDF ) (1694KB)
Export: BibTeX | EndNote (RIS)

Abstract Magnetic hydrogel combines the properties and advantages of magnetic material, polymer material and hydrogel into a single platform, which is widely used as biomaterials. Because of their excellent magnetic properties and biocompatibility, magnetic hydrogel can be used as multifunctional drug delivery systems (DDS) for magnetic sensitive drug release, targeting, hyperthermia and magnetic resonance imaging (MRI). In this paper, recent progresses of the preparation and applications of magnetic hydrogel as drug delivery systems are reviewed. And the drug release mechanism of magnetic hydrogel, including the ON/OFF release model and temperature-sensitive release behavior are described in detail.

Key words： magnetic nanoparticles hydrogel drug carrier magnetic targeting magnetic hyperthermia

Published: 10 August 2017 Online: 2018-05-04

CLC number:

O631

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HAN Xiaodong
	ZHANG Wen
	YU Kun
	JIA Qingming
	SHAN Shaoyun
	SU Hongying

Cite this article:

HAN Xiaodong,ZHANG Wen,YU Kun, et al. Advances in Application of Magnetic Hydrogels as Drug Carriers[J]. Materials Reports, 2017, 31(15): 30-35.

URL:

https://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2017.015.005 OR https://www.mater-rep.com/EN/Y2017/V31/I15/30

1 Tietze R, Lyer S, Dürr S, et al. Nanoparticles for cancer therapy using magnetic forces[J]. Nanomedicine, 2017,7(3):447.
2 Parker B S, Rautela J, Hertzog P J. Antitumour actions of interfe-rons: Implications for cancer therapy[J]. Nat Rev Cancer,2016,16(3):131.
3 Carr C, Ng J, Wigmore T, et al. The side effects of chemotherapeutic agents[J]. Current Anaesthesia Critical Care,2008,19(2):70.
4 Miller K D, Siegel R L, Lin C C, et al. Cancer treatment and survivorship statistics, 2016[J]. Ca A Cancer J Clinicians,2016,66(4):271.
5 Li X L, Oduola W O, Qian L, et al. Integrating multiscale modeling with drug effects for cancer treatment[J]. Cancer Informatics,2016,14(S5):21.
6 Jaiswal M K, Pradhan L, Vasavada S, et al. Magneto-thermally responsive hydrogels for bladder cancer treatment: Therapeutic efficacy and in vivo biodistribution[J]. Colloids Surf B Biointerfaces,2015,136:625.
7 Ju Y C, Thapa R K, Yong C S, et al. Nanoparticle-based combination drug delivery systems for synergistic cancer treatment[J]. J Pharmaceutical Investigation,2016,46(4):325.
8 Zhang T, Cai S, et al. Hyaluronan-lysine cisplatin drug carrier for treatment of localized cancers: Pharmacokinetics, tolerability, and efficacy in rodents and canines[J]. J Pharmaceutical Sci,2016, 105(6):1891.
9 Emanuel N, Neuman M, Barak S. Sustained-release drug carrier composition: US, US8877242[P].2014.
10 Brandl F, Kastner F, Gschwind R M, et al. Hydrogel-based drug delivery systems: Comparison of drug diffusivity and release kinetics[J]. J Controlled Release,2010,142(2):221.
11 Ai H. Layer-by-layer capsules for magnetic resonance imaging and drug delivery[J]. Adv Drug Delivery Rev,2011,63(9):772.
12 Kwon G S, Okano T. Polymeric micelles as new drug carriers[J]. Adv Drug Delivery Rev,1996,21(2):107.
13 Su H, Liu Y, Wang D, et al. Amphiphilic starlike dextran wrapped superparamagnetic iron oxide nanoparticle clsuters as effective magnetic resonance imaging probes[J]. Biomaterials,2012,34(4):1193.
14 Wang Q Y, Su H Y, Xia C C, et al. Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes[J]. Sci Bull,2009,54(17):2925.
15 Li Y, Huang G, Zhang X, et al. Magnetic Hydrogels and their potential biomedical applications[J]. Adv Funct Mater,2013,23(6):660.
16 Ahmad H, Sultana M S, Alam M A, et al. Evaluating a simple blending approach to prepare magnetic and stimuli-responsive composite hydrogel particles for application in biomedical field[J]. Express Polym Lett,2016,10(8):664.
17 Tóth I Y, Veress G, Szekeres M, et al. Magnetic hyaluronate hydrogels: Preparation and characterization[J]. J Magn Magn Mater,2014,380:175.
18 Wang Y H, Xia M G, Wu Y T, et al. Preparation and characterization of PNIPAM nanocomposite hydrogels with controllable magne-tic properties[J].J Funct Polym,2015,28(1):32(in Chinese).
王益亨, 夏梦阁, 武永涛,等. 磁性能可控的聚(N-异丙基丙烯酰胺)基纳米复合水凝胶的制备与表征[J]. 功能高分子学报,2015,28(1):32.
19 Zhao W, Odelius K, Edlund U, et al. In situ synthesis of magnetic field-responsive hemicellulosehydrogels for drug delivery[J]. Biomacromolecules,2015,16(8):2522.
20 Jiang L, Liu P. Design of magnetic attapulgite/fly ash/poly(acrylic acid) ternary nanocomposite hydrogels and performance evaluation as selective adsorbent for Pb²⁺ ion[J]. ACS Sustainable Chem Eng,2014, 2(7):1785.
21 Messing R, Frickel N, Belkoura L, et al. Cobalt ferrite nanoparticles as multifunctional cross-linkers in PAAm ferrohydrogels[J]. Macromolecules,2011,44:2990.
22 Guo X, Wang L, Wei X, et al. Polymer-based drug delivery systems for cancer treatment[J]. J Polym Sci A Polym Chem,2016,54(22):3525.
23 Galot R, Machiels J P. Safety of drug treatments for head and neck cancer[J]. Expert Opinion Drug Safety, 2016,15(11):1527.
24 Rao S Q, Xue Z S, Lu G H. Preparation and application of magnetic sensitive hydrogel[J].New Chem Mater,2013,41(11):187(in Chinese).
饶思奇, 徐祖顺, 路国红. 磁性水凝胶的制备及其应用研究进展[J]. 化工新型材料,2013,41(11):187.
25 Uva M, Pasqui D, Mencuccini L, et al. Influence of alternating and static magnetic fields on drug release from hybrid hydrogels containing magnetic nanoparticles[J]. J Biomater Nanobiotechnol,2014,5(4):924.
26 Satarkar N S, Hilt J Z. Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release[J]. J Controlled Release,2008,130(3):246.
27 Campbell S, Maitland D, Hoare T. Enhanced pulsatile drug release from injectable magnetic hydrogels with embedded thermosensitive microgels[J]. ACS Macro Lett,2015,4(3):312.
28 Zhang N, Lock J, Sallee A, et al. Magnetic nanocomposite hydrogel for potential cartilage tissue engineering: Synthesis, characterization, and cytocompatibility with bone marrow derived mesenchymal stem Cells[J]. ACS Appl Mater Interfaces,2015,7(37):20987.
29 Zhang D, Sun P, Li P, et al. A magnetic chitosan hydrogel for sustained and prolonged delivery of Bacillus Calmette-Guerin in the treatment of bladder cancer[J]. Biomaterials,2013,34(38):10258.
30 Gobbo O L, Sjaastad K, Radomski M W, et al. Magnetic nanoparticles in cancer theranostics[J]. Theranostics,2015,5(511):1249.
31 Huang J, Xue Y, Cai N, et al. Efficient reduction and pH co-triggered DOX-loaded magnetic nanogel carrier using disulfide crosslin-king[J]. Mater Sci Eng C: Mater Biol Appl,2015,46:41.
32 Sung B, Shaffer S, Sittek M, et al. Alternating magnetic field-responsive hybrid gelatin microgels for controlled drug release[J]. J Visualized Experiments,2016,108:53680.
33 Reddy N N, Ravindra S, Reddy N M, et al. Temperature responsive hydrogel magnetic nanocomposites for hyperthermia and metal extraction applications[J]. J Magn Magn Mater,2015,394:237.
34 Zhu X, Zhang H, Huang H, et al. Functionalized graphene oxide-based thermosensitive hydrogel for magnetic hyperthermia therapy on tumors[J]. Nanotechnology,2015,26(36):365103.
35 Kim J I, Chun C, Kim B, et al. Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform[J]. Biomaterials,2012,33(1):218.
36 Wang X, Niu D, Li P, et al. Dual-enzyme-loaded multifunctional hybrid nanogel system for pathological responsive ultrasound imaging and T2-weighted magnetic resonance imaging[J]. ACS Nano,2015, 9(6):5646.