含硼荧光材料及其在硼中子俘获治疗中的应用

doi:10.11896/cldb.24090118

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Abstract Boron neutron capture therapy (BNCT), as a binary targeted radiotherapy, has shown strong anti-cancer potential. This treatment is highly selective and lethal to tumor cells, and its effectiveness mainly depends on the accumulation of sufficient concentrations of ¹⁰B in the tumor. Real-time observation of boron’s tissue distribution and metabolism during the BNCT process has always been a challenge in the treatment. Fluorescence imaging, as a potential sensitive spectral technique, is a reliable choice for evaluating boron distribution in tissues. Therefore, research combining BNCT with fluorescence imaging has attracted widespread attention. In this review, we focus on the types and applications of boron-containing fluorescent materials and provide a detailed introduction to the fluorescent materials applied in BNCT. Further, we discuss the technical bottlenecks of these boron-containing materials in BNCT and possible solutions. Finally, we look forward to the feasible design and application prospects of boron-containing fluorescent materials in BNCT, providing new guidance for the design of boron-containing fluorescent materials.

Key words： boron neutron capture therapy imaging fluorescent molecule porous material

Published: 10 March 2025 Online: 2025-03-18

CLC number:

R914.2

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	Articles by authors
	PANG Miao
	ZHONG Tianyuan
	PAN Yong
	QI Yanxin
	HUANG Yubin

Cite this article:

PANG Miao,ZHONG Tianyuan,PAN Yong, et al. Boron-containing Fluorescent Materials and Their Application in Boron Neutron Capture Therapy[J]. Materials Reports, 2025, 39(5): 24090118-6.

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https://www.mater-rep.com/EN/10.11896/cldb.24090118 OR https://www.mater-rep.com/EN/Y2025/V39/I5/24090118

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