一种新型可注射KGM/纤维复合骨水泥治疗骨缺损

doi:10.11896/cldb.24070058

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Abstract The injection of bone cement is a promising surgical intervention for the treatment of osteoporosis.The aim of this study was to formulate a novel injectable bioactive bone cement to adress such medical problems.The bone cement primarily consists of tricalcium phosphate (β-TCP),konjac glucomannan (KGM),and hydroxyapatite whisker (HAw).An orthogonal experiment was designed to generate multiple sets of new composite calcium phosphate cement (NCPC) samples,and their setting times were measured.The in vitro compatibility of the new bone cement was assessed through relative cell proliferation rate (RGR) and in vitro cell growth experiments.Mechanical strength and porosity tests were conducted for each group of bone cement,and cross-sectional morphology was observed.The results demonstrate that the bone cement exhibits favorable properties such as self-curing,mechanical robustness,and resistance to collapse.
The optimum formulation involves a doping ratio of 5/15(wt%) HAw and HA,an additional amount of 1.2wt% KGM,and a liquid citric acid concentration of 2wt%.Porosity tests confirmed that the material has high compressive strength and a favorable porosity of 27%,creating conducive conditions for cell growth,proliferation,and material degradation.Moreover,in vitro cell culture experiments revealed excellent biocompatibility of the material.Consequently,the developed NCPC emerges as a potential candidate material for applications of bone implantation.

Key words： bone cement,calcium phosphate,orthogonal test,setting time,konjac glucomannan

Published: 10 October 2025 Online: 2025-09-24

CLC number:

O64

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	Articles by authors
	IU Hanwu
	ZHAO Qiang
	XIAO Ting
	YAN Tingting1

Cite this article:

IU Hanwu,ZHAO Qiang,XIAO Ting, et al. A Novel Injectable KGM/Fiber Composite Bone Cement for Bone Defect[J]. Materials Reports, 2025, 39(19): 24070058-8.

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https://www.mater-rep.com/EN/10.11896/cldb.24070058 OR https://www.mater-rep.com/EN/Y2025/V39/I19/24070058

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