可注射止血水凝胶的设计原理及粘附能力增强策略

doi:10.11896/cldb.24080189

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Abstract Most injectable hydrogels either fail to cohere due to a lack of mechanical strength or have insufficient bonding capacity to sustain adhesion due to insufficient interfacial interaction between tissue and biomaterial. Ideal hydrogel materials should have optimal cohesive strength to mimic the stiffness and elasticity of natural tissues, as well as appropriate bond strength to seal wounds with physical methods and to resist mechanical movement with some intensity. Indeed, the adhesion performance of hydrogel is determined by the bonding and cohesion together;within the appropriate equilibrium, a single increase in cohesion or adhesion can produce adhesion enhancement, but once the balance is destroyed, the two will be opposing constraints on each other. Learning the design principles and adhesion enhancement strategies of injectable hemostatic hydrogels is the key to the research and technology transformation of hemostatic hydrogels. This paper introduces the design principles of high-strength injectable hydrogels and analyzes the design strategies and methods of adhesion enhancement from the dimensions of cohesion and bonding with examples. Finally, we summarize and look forward to the precautions in the process of designing injectable hydrogels as well as the future development direction.

Key words： injectable hemostatic hydrogel adhesion capacity cohesive strength bond strength

Published: Online: 2025-08-28

CLC number:

R318.08

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	Articles by authors
	LIU Shuhan
	DING Sheng
	HOU Kexin
	CHENG Yali
	ZHANG Shaohui
	LI Fan
	YANG Kun

Cite this article:

LIU Shuhan,DING Sheng,HOU Kexin, et al. Design Principle and Adhesion Enhancing Strategies of Injectable Hemostatic Hydrogel[J]. Materials Reports, 2025, 39(17): 24080189-12.

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https://www.mater-rep.com/EN/10.11896/cldb.24080189 OR https://www.mater-rep.com/EN/Y2025/V39/I17/24080189

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