金纳米颗粒应用于肿瘤显像和治疗的研究进展

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Abstract Gold nanoparticles (GNPs) has received great attention in the field of tumor imaging and therapy because of its excellent physical and chemical properties. GNPs provides high X-ray attenuation for Computed tomography (CT) imaging. After receiving the excitation light, plasmon enhanced fluorescence (PEF) can be produced by GNPs to enhance the effect of fluorescence imaging. GNPs can produce strong electromagnetic fields under excitation light, which can be used for surface enhanced Raman scattering. There is a high localized surface plasmon re-sonance (LSPR) effect of GNPs in the near infrared region, which can be applied for photoacoustic imaging (PA). GNPs are known to possess radiosensitizing activity,which can improve the effect of radiotherapy by producing the secondary radiation upon X-ray irradiation. Due to the broad absorption in the near-infrared range, GNPs shows a significant photothermal effect,it can convert light energy into heat energy, thus ablate tumor tissues effectively. In addition, the surface of GNPs can be easily modified to deliver drugs and nucleic acids, target tumors and improve biocompatibility. This article mainly reviews the research progress of GNPs in tumor imaging and therapy.

Key words： gold nanoparticles tumor imaging therapy

Published: 16 July 2021

CLC number:	R730.49
	R730.59

Fund:Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS 2016-I2M-3-022), the Fundamental Research Funds for the Central Universities (3332018117, 3332020057), the Science and Technology Project of Tianjin (18ZXXYSY00110), and the Natural Science Foundation of Tianjin(18JCQNJC09500).

About author:: Chen Zhao is currently a master's degree student at Tianjin University of Traditional Chinese Medicine. His research has focused on the preparation and application of nanomaterials.Yiliang Li, PhD, researcher, doctoral supervisor. His research has focused on the basic research work in chemical biology and molecular imaging; research on the discovery of original innovative drugs for molecular targets such as inflammation and DNA damage repair.Wenbin Hou, PhD, researcher. Mainly engaged in the discovery, research and development of innovative Chinese medicine and natural medicine.

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	ZHAO Chen
	BI Changfen
	ZHENG Baoxin
	HOU Wenbin
	LI Yiliang

Cite this article:

ZHAO Chen,BI Changfen,ZHENG Baoxin, et al. Research Progress on Application of Gold Nanoparticles in Tumor Imaging and Therapy[J]. Materials Reports, 2021, 35(Z1): 322-327.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2021/V35/IZ1/322

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