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| Synthesis and Characterization of Amphiphilic Cyclic-poly(ε-Caprolactone)-b-poly(N-Vinylpyrrolidone) Copolymer |
| YANG Dandan, NIE Kangming, ZHANG Yanhao, WANG Song
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| Anhui Province Key Laboratory of Environment-friendly Polymer Materials,College of Chemistry and Chemical Engineering,Anhui University, Hefei 230601 |
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Abstract The amphiphilic cyclic-poly(ε-caprolactone)-b-poly(N-vinylpyrrolidone) copolymer (cyclic-PCL-b-PVP) was synthesized via atom transfer radical polymerization (ATRP) and click chemistry. The structure, molecular weight and molecular weight distribution of the copolymer were characterized by FT-IR, 1H-NMR, GPC respectively. The thermodynamic properties and the hydrophilicity of the copolymer were studied by TGA and contact angle measurement. Our results indicated an evidently higher thermal stability and a different hydrophilicity of the cyclic copolymer compared with linear-PCL-b-PVP.
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Published: 25 June 2017
Online: 2018-05-08
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1 Yamamoto T, Tezuka Y. Topological polymer chemistry: A cyclic approach toward novel polymer properties and functions [J].Polym Chem,2011,2(9):1930.
2 Wan X J, Liu T, Liu S Y. Synthesis of amphiphilic tadpole-shaped linear-cyclic diblock copolymers via ring-opening polymerization directly initiating from cyclic precursors and their application as drug nanocarriers [J]. Biomacromolecules,2011,12(4):1146.
3 Shi G Y, Pan C Y. Synthesis of well-defined figure-of-eight-shaped polymers by a combination of ATRP and click chemistry[J]. Macromol Papid Commun,2008,29:1672.
4 Luca A C D, Stevens J S, Schroeder S L M, et al . Immobilization of cell-binding peptides on poly-ε-caprolactone film surface to biomimic the peripheral nervous system [J].J Biomedical Mater Res A,2013,101(2):491.
5 Labet M, Thielemans W. Synthesis of polycaprolactone: A review [J]. Chem Soc Rev,2009,38(12):3484.
6 Hajar S, et al. In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly (ε-caprolactone) [J]. Biomaterials,2012,33(17):4309.
7 Zhu Z S, Li Y, Li X L, et al. Paclitaxel-loaded poly-(N-vinylpyrrolidone)-b-poly(ε-caprolactone)[J]. J Controlled Release,2010,142(3):438.
8 Bartolozzi I, Solaro R, Schacht E, et al. Hydroxyl end-capped macromers of N-vinyl-2-pyrrolidinone as precursors of amphiphilic block copolymers [J]. Eur Polym J,2007,43(11):4628.
9 Luo L B, Ranger M, Lessard D G, et al. Novel amphiphilic diblock copolymer of low molecular weight poly(N-vinylpyrrolidone)-block-poly(D,L-lactide): Synthesis, characterization and micellization[J]. Macromolecules,2004,37(11):4008.
10 Persenaire O, Alexandre M, Dege′e P, et al. Mechanism and kine-tics of thermal degradation of poly (ε-caprolactone) [J]. Biomacromolecules,2001,2(1):288. |
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2017, Vol. 31 
