双醛羧甲基纤维素-胶原复合止血材料的研制

doi:10.11896/j.issn.1005-023X.2018.20.024

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Abstract Dialdehyde carboxymethyl cellulose sodium (DCMC) was selectively oxidized utilizing sodium carboxymethyl cellulose (CMC) and collagen (Col) as raw materials, and the collagen was cross-linked and modified to obtain a new type collagen hemostatic sponge DCMC-Col. The modified DCMC-Col composites were evaluated by infrared spectroscopy, circular dichroism, differential scanning calorimetry, atomic force microscopy and scanning electron microscopy. The results indicated that the thermal stability of the modified collagen was significantly improved, and the triple helix structure of collagen was not destroyed. The total clotting time test confirmed that the hemostatic property of the sponge was optimal when the dosage of DCMC was 15%. The results of water absorption, hemolysis and MTT test results demonstrated that the properties of DCMC-Col could meet the requirements of hemosta-tic materials and it had a good biocompatibility. Therefore, DCMC-Col composite sponge is a new type of hemostatic materials with potential medical applications value.

Key words： carboxymethyl cellulose type Ⅰ collagen modification hemostatic materials

Published: 22 November 2018

CLC number:

O636

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	Articles by authors
	BAI Zhongxiang
	DAN Nianhua
	DAN Weihua
	GAO Ran

Cite this article:

BAI Zhongxiang,DAN Nianhua,DAN Weihua, et al. Preparation of Dialdehyde Carboxymethyl Cellulose-Collagen Composite Hemostatic Material[J]. Materials Reports, 2018, 32(20): 3628-3633.

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http://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2018.20.024 OR http://www.mater-rep.com/EN/Y2018/V32/I20/3628

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