用于构建可溶性微针的基质材料及其复合材料<sup>*</sup>

doi:10.11896/j.issn.1005-023X.2017.019.018

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Abstract As a novel transdermal drug delivery system, dissolvable microneedle has broken the limitations of traditional transdermal formulations which are not able to deliver macromolecular. Besides the aspect of macromolecular delivery, dissolvable microneedles have numerous advantages including small enough to avoid causing pain, minimal skin trauma, no bleeding or introduction of pathogens, good biocompatibility, easy to self-administration, etc. The study of dissolvable microneedle has recently become a hot topic. The choice of matrix materials directly affects the preparation process of microneedle, as well as the properties of skin puncturing and drug releasing. This paper introduces the research status of dissolvable microneedle, classifies and introduces the matrix materials, then summarizes the use of their compounds. The properties of ductile materials and brittle materials and their synergistic effects after composite are introduced as well. Finally, the existing problems and research directions in this field are discussed.

Key words： dissolvable microneedle material classification composite ductile material brittle material

Published: 10 October 2017 Online: 2018-05-07

CLC number:	R944.9
	TB332

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	Articles by authors
	ZHANG Jie
	MA Fengsen
	ZHAN Haohui
	HUANG Yingcong

Cite this article:

ZHANG Jie,MA Fengsen,ZHAN Haohui, et al. Matrix Materials and Their Composites for Dissolvable Microneedle Construction: a Review[J]. Materials Reports, 2017, 31(19): 129-134.

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https://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2017.019.018 OR https://www.mater-rep.com/EN/Y2017/V31/I19/129

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