用于减少再狭窄的食管支架表面功能化策略

doi:10.11896/cldb.25050047

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Abstract Malignant esophageal obstruction, predominantly caused by tumors, leads to dysphagia. Stent implantation serves as a key therapeutic intervention for relieving this malignant stenosis. However, post-stent restenosis, primarily driven by persistent tumor proliferation and excessive tissue hyperplasia, significantly compromises patient quality of life and overall survival. Recent years have witnessed significant research endeavors globally focused on developing multimodal therapeutic strategies centered on esophageal stents, leveraging surface functionalization techniques to confer anti-restenotic properties. These advancements encompass a spectrum of functionalized stents, including anti-adhesion stents, drug-eluting stents, photothermal stents, internal radiation stents, photodynamic stents, and synergistic therapy stents. This paper provides a systematic review of the design concepts and evolution of these diverse stent types. Furthermore, it proposes future research directions for esophageal anti-tumor stents, focusing on enhancing long-term biocompatibility/adaptability and optimizing targeted therapeutic efficacy.

Key words： esophageal stent restenosis malignant obstruction surface functionalization multimodal therapy

Published: 25 April 2026 Online: 2026-05-06

CLC number:

R318.08

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	Articles by authors
	LIU Xiaofeng
	LI Chaojing
	WANG Fujun
	WANG Lu

Cite this article:

LIU Xiaofeng,LI Chaojing,WANG Fujun, et al. Surface Functionalization Strategies for Esophageal Stents to Reduce Restenosis[J]. Materials Reports, 2026, 40(8): 25050047-7.

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https://www.mater-rep.com/EN/10.11896/cldb.25050047 OR https://www.mater-rep.com/EN/Y2026/V40/I8/25050047

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