| METALS AND METAL MATRIX COMPOSITES |
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| Processing and Surface Treatment of Nickel-Titanium (NiTi) Alloy Cardiovascular/Cerebrovascular Stents |
| LI Jingtong1, HAN Rizheng1, JIN Wei1, CHEN Song2, ZHANG Xing1, BAI Yun1,*
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1 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China 2 Wuhan Vickor Medical Technology Co., Ltd., Wuhan 430000, China |
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Abstract Nickel-titanium (NiTi) alloy stents have become indispensable in the treatment of cardiovascular and cerebrovascular diseases due to their super elasticity, shape memory effect, and exceptional biocompatibility. However, their clinical efficacy critically hinges on the compatibility between fabrication methodologies and surface modification strategies. This review systematically evaluates the technical characteristics of two predominant NiTi stent processing techniques——laser cutting and fine braiding, and their application-specific discrepancies in cardiac valve stents, coronary stents, peripheral stents, and cerebrovascular stents. Laser-cutting stents, featuring closed-loop architectures with high geometric precision, demonstrate superior radial supportive strength, rendering them optimal for valvular and coronary pathologies requiring mechanical stability. In contrast, fine braiding stents achieve structural reconfigurability through tunable braiding patterns, prioritizing compliance with the biomechanical demands of intracranial aneurysms and tortuous peripheral vasculature. Surface functionalization strategies are further customized for distinct clinical scenarios:valvular stents emphasize inorganic coatings with anti-calcification capacity, coronary stents predominantly center on drug-eluting coatings, peripheral stents integrate antibacterial and antithrombogenic functions, while cerebrovascular stents employ ultra-thin graft layers to ba-lance immediate anticoagulation with neurological safety. This paper reveals the deep correlation between process selection and clinical needs, providing a theoretical basis for the precise design and application adaptation of nickel titanium stents. It also looks forward to the development trends of composite processes, intelligent materials, and dynamic functional integration in the processing and surface treatment of nickel titanium alloy stents in the future.
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Published: 25 February 2026
Online: 2026-02-13
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1 Mantovani D. The Journal of the Minerals, Metals & Materials Society, 2000, 52, 36. 2 Otsuka K, Ren X. Progress in Materials Science, 2005, 50, 511. 3 Duerig T, Pelton A, Stöckel D. Materials Science and Engineering:A, 1999, 273, 149. 4 Imbeni V, Martini C, Prandstraller D, et al. Wear, 2003, 254, 1299. 5 Li Z, Yan W, Feng H. Journal of Biomedical Engineering, 2020, 37(2), 334(in Chinese). 李治国, 闫文刚, 冯海全. 生物医学工程学杂志, 2020, 37(2), 334. 6 Carbonaro D, Villa E, Gallo D, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2024, 158, 106653. 7 Li D, Wang J, Du C, et al. Materials & Design, 2025, 250, 113624. 8 Safdel A, Torbati-Sarraf H, Elbestawi M A. Journal of Alloys and Compounds, 2023, 954, 170196. 9 Guo Y, Yan X, Yang Y, et al. Ceramics International, 2024, 50, 2479. 10 Wei C, Tan J, Xing S, et al. Chemical Engineering Journal, 2025, 507, 160730. 11 Wei J, Yang L, Wang G, et al. Frontiers in Materials, 2024, 11, 1431992. 12 Zhao Y, Li J, Guo K, et al. Journal of Manufacturing Processes, 2020, 58, 787. 13 Ahadi F, Azadi M, Biglari M, et al. Heliyon, 2023, 9, 13575. 14 湃生科技(常州)有限公司. 湃生首页/解决方案/激光加工. https://www.paithon. cn/solutions/ntjg47. html. 15 Liu L, Li B D, Tong F Y, et al. Applied Physics A, 2016, 122, 638. 16 Sun X, Wei X, Li Z, et al. International Journal of Precision Engineering and Manufacturing, 2021, 22, 1237. 17 Li Y. Finite element analysis and experimental study on laser machining of Nitinol cardiovascular stent. Master’s Thesis, Shandong University of Technology, China, 2022 (in Chinese). 李越. 镍钛合金心血管支架激光加工有限元分析及试验研究. 硕士学位论文, 山东理工大学, 2022. 18 Liu X, Li Z, Liu Y, et al. Non-traditional Machining, 2022(11), 45(in Chinese). 刘旭东, 李志永, 刘育辰, 等. 制造技术与机床, 2022(11), 45. 19 Ou Z, Brian W. Industrial Laser Solutions, 2017, 35. 20 Zhang Y, Wang L, Gong J. Acta Photonica Sinica, 2016, 45, 514002. 21 Yue D, Sun H, Liu Z, et al. Laser & Infrared, 2021, 51(4), 441(in Chinese). 岳端木, 孙会来, 刘泽林, 等. 激光与红外, 2021, 51(4), 441. 22 Armfield D, Boxwell S, McNamara L, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2024, 157, 106650. 23 Kumar G P, Mathew L. Computers in Biology and Medicine, 2012, 42, 1060. 24 Shen X, Xu Y, Li H, et al. Computer Methods and Programs in Biomedicine, 2024, 250, 108173. 25 Cabrera M S, Oomens C W J, Baaijens F P T. Journal of the Mechanical Behavior of Biomedical Materials, 2017, 68, 252. 26 Chenrayan V, Palanisamy D, Mani K, et al. Heliyon, 2024, 10, 28057. 27 Muhammad N, Whitehead D, Boor A, et al. Applied Physics A, 2012, 106, 607. 28 Fu C H, Liu J F, Guo A. Applied Surface Science, 2015, 353, 291. 29 Azaouzi M, Lebaal N, Makradi A, et al. Materials & Design, 2013, 50, 917. 30 Muhammad N, Al Bakri Abdullah M M, Saleh M S, et al. Key Engineering Materials, 2015, 660, 345. 31 Morris R I, Jackson N, Khan T, et al. European Journal of Vascular and Endovascular Surgery, 2022, 63, 613. 32 He R, Zhao L, Silberschmidt V, et al. Materials Science & Engineering C, 2021, 130, 112462. 33 Chen Y, Feng H, Bai Y, et al. Engineering Failure Analysis, 2025, 169, 109199. 34 Kim J, Kim H, Park C H, et al. World Neurosurgery, 2024, 186, 87. 35 Shobayashi Y, Tanoue T, Tateshima S, et al. Medical Engineering & Physics, 2010, 32, 1015. 36 Vieira-Leite C, Mosqueira A J, Arias-Rivas S, et al. World Neurosurgery, 2020, 133, 487. 37 Buonomo O, Mormina E, Caragliano A A, et al. Heliyon, 2021, 7, 08040. 38 Martin G H, Saqib N U, Safi H J. Annals of Vascular Surgery, 2016, 34, 268. 39 Lv X, Li Y, Jiang C, et al. European Journal of Radiology, 2011, 79, 317. 40 古河科技材料株式会社. 形状记忆·超弹性镍钛合金>应用领域/产品中心>支架. https://www.furukawa-ftm.com/tokusyu/chinese/product/stent/. 41 Zhang P. Technical Textiles, 1998(12), 33(in Chinese). 张佩华. 产业用纺织品, 1998(12), 33. 42 Zaccaria A, Pennati G, Petrini L, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2021, 119, 104560. 43 Carbonaro D, Villa E, Gallo D, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2024, 158, 106653. 44 Xue W, Gao J, Lin J, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 78, 74. 45 Galzerano G, Pasqui E, Anzaldi M G, et al. Journal of Vascular Surgery, 2024, 79, 41. 46 León L R, Dieter R S, Gadd C L, et al. Journal of Vascular Surgery, 2013, 57, 1014. 47 Yang M, Shi B, Ma L, et al. Annals of Vascular Surgery, 2022, 85, 183. 48 Nakama T, Obunai K, Muraishi M, et al. JACC:Cardiovascular Interventions, 2020, 13, 71. 49 Gory B, Spiotta A M, Mangiafico S, et al. American Journal of Neuroradiology, 2016, 37, 130. 50 Dinc H, Saatci I, Oguz S, et al. Neuroradiology, 2021, 63, 943. 51 Alherz A I, Tanweer O, Flamini V. Journal of Biomechanics, 2016, 49, 2420. 52 Feng Z, Zhang L, Li Q, et al. Journal of Clinical Neuroscience, 2015, 22, 1288. 53 Imahori T, Shose H, Okamura Y, et al. World Neurosurgery, 2019, 132, 177. 54 De Bock S, Iannaccone F, De Santis G, et al. Journal of Biomechanics, 2012, 45, 1353. 55 Silvestri O, Accarino G, Turchino D, et al. Healthcare, 2024, 12, 120. 56 Ma J, You Z, Peach T, et al. Journal of Biomechanics, 2015, 48, 4206. 57 Hoseini F, Bellelli A, Mizzi L, et al. Materials Today Communications, 2024, 41, 111042. 58 Avgerinos E, Jalaie H, Phlebolymphology, 2023, 30, 118. 59 Lao X, Liu X, Han H, et al. Chinese Journal of Rare Metals, 2008, 32(2), 207. 劳晓东, 刘欣杰, 韩会民, 等. 稀有金属, 2008, 32(2), 207. 60 Duan L, He Y, Li T, et al. Chinese Journal of Interventional Radiology (Electronic Edition), 2022, 10(11), 83. 段林, 何艳艳, 李天晓, 等. 中华介入放射学电子杂志, 2022, 10(11), 83. 61 Miao W, Mi X, Xu G, et al. Rare Metals, 2006, 25, 243. 62 Zhao H, Van Humbeeck J, De Scheerder I. Surface Engineering, 2001, 17, 451. 63 Chu C L, Wang R M, Hu T, et al. Materials Science and Engineering:C, 2008, 28, 1430. 64 Kato S, Ban Y, Ota T, et al. Micromachines, 2024, 15, 213. 65 Chun Y J, Levi D S, Mohanchandra K P, et al. Smart Materials and Structures, 2010, 19, 105021. 66 Du H, Wu C, Li D, et al. Journal of Materials Research and Technology, 2023, 25, 55. 67 Nozaki K, Shinonaga T, Ebe N, et al. Materials Science and Enginee-ring:C, 2015, 57, 1. 68 Ding Y, Leng Y, Huang N, et al. Journal of Biomedical Materials Research Part A, 2013, 101, 622. 69 Lu J, Rao M P, MacDonald N C, et al. Acta Biomaterialia, 2008, 4, 192. 70 Zhang H, Zhang K, Liu P, et al. Nonferrous Metal Materials and Engineering, 2018, 39(6), 48(in Chinese). 张涵, 张柯, 刘平, 等. 有色金属材料与工程, 2018, 39(6), 48. 71 Wang F. ALD mediated heparin grafting on nitinol for self-expanded carotid stents. Master’s Thesis, Nanjing University, China, 2016 (in Chinese). 王菲. 原子层沉积(ALD)介导的肝素接枝颈动脉支架. 硕士学位论文, 南京大学, 2016. 72 Shen Y. Study on surface modification and biocompatibility of NiTi alloy intravascular stents. Master’s Thesis, Chongqing University, China, 2005 (in Chinese). 沈阳. NiTi合金血管内支架表面改性及其生物相容性研究. 硕士学位论文, 重庆大学, 2005. 73 Muthumeenal M, Rajalakshmi M, Indirajith R, et al. Applied Physics A, 2025, 131, 245. 74 Yu H, Liu Y, Wang Y, et al. Progress in Natural Science:Materials International, 2016, 26, 584. 75 Sargeant T D, Rao M S, Koh C Y, et al. Biomaterials, 2008, 29, 1085. 76 Wang S, Chen Z, Lin Q, et al. Tropical Journal of Pharmaceutical Research, 2017, 16, 2033. 77 Simsekyilmaz S, Liehn E A, Weinandy S, et al. Plos One, 2016, 11, 0155829. 78 Dadafarin H, Konkov E, Vali H, et al. Molecules, 2024, 29, 4927. 79 Park C, Kim S, Kim H E, et al. Surface and Coatings Technology, 2016, 305, 139. 80 Liu M, Yang D, Wang W, et al. Journal of Functional Materials, 2000(6), 584(in Chinese). 刘敬肖, 杨大智, 王伟强, 等. 功能材料, 2000(6), 584. 81 Serruys P, Hout B, Bonnier H, et al. The Lancet, 1998, 352, 673. 82 Lammer J, Zeller T, Hausegger K A, et al. Journal of the American College of Cardiology, 2013, 62, 1320. 83 Feng B. Study on design of peripherial artery drug-eluting stent with sirolimus and heparin and its inhibition of in-stent restenosis. Ph. D. Thesis, China Medical University, China, 2007 (in Chinese). 冯博. 国产外周动脉雷帕霉素—肝素洗脱支架预防再狭窄研究. 博士学位论文, 中国医科大学, 2007. 84 Wang M, Wan Y, Liu W, et al. Polymers for Advanced Technologies, 2023, 34, 2663. 85 Duan L, He Y, Wu H, et al. Advanced Materials Interfaces, 2023, 10, 2300028. 86 Peng Q, Guo R, Zhou Y, et al. Macromolecular Bioscience, 2023, 23, 2200402. 87 Tepe G, Schmehl J, P Wendel H, et al. Biomaterials, 2006, 27, 643. 88 Bakhshi R, Darbyshire A, Evans J E, et al. Colloids and Surfaces B:Biointerfaces, 2011, 86, 93. 89 Lai Y L, Cheng P Y, Yang C C, et al. Thin Solid Films, 2018, 649, 192. 90 Li Q. In vitro study on the biological properties of a new type EPC capture coronary stent material. Master’s Thesis, Jilin University, China, 2014 (in Chinese). 李倩. RGD修饰的内皮祖细胞捕获支架涂层材料体外生物学性能研究. 硕士学位论文, 吉林大学, 2014. |
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