| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Research Progress of Conductive Hydrogels for Medical Applications |
| YAO Boxing1,3, MA Zhao4, YANG Kuan1,2,*, QIU Lin1,2, LIN Zifan1,2, WANG Shulei1,2
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1 Xi’an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi’an Medical University, Xi’an 710021, China 2 Institute of Drug Research, College of Pharmacy, Xi’an Medical University, Xi’an 710021, China 3 School of Pharmacy, Chengdu Medical College, Chengdu 610500, China 4 Shaanxi Panlong Pharmaceutical Group Limited by Share LTD., Xi’an 710025, China |
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Abstract Conductive hydrogels, which integrate hydrophilic matrices with conductive media, not only retain the flexibility and biocompatibility of conventional hydrogels but also exhibit superior electrical conductivity. These unique material properties position them for broad application prospects in fields such as medical monitoring, artificial skin, implantable bioelectronics, and tissue engineering. This review focuses on the research progress of conductive hydrogels in the medical field, detailing their classification into electronic conductive hydrogels, ionic conductive hydrogels, and intrinsically conductive hydrogels, as well as the methods for their preparation. It discusses the advantages and disadvantages of each type of conductive hydrogel and their potential to improve the mechanical properties and conductivity of materials. It ends with a prospective discussion on issues challenging current research and future trends.
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Published: 10 November 2025
Online: 2025-11-10
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1 Zhi H, Zhang X B, Wang F Y, et al. ACS Applied Materials & Interfaces, 2022, 14(46), 52422. 2 Fu F F, Wang J L, Zeng H B, et al. ACS Materials Letters, 2020, 2(10), 1287. 3 Bai Y, Yan S Q, Wang Y B, et al. ACS Applied Materials & Interfaces, 2023, 15(41), 48744. 4 Liu Y C, Zou X, Luo B, et al. Chemical Engineering Journal, 2025, 503, 158288. 5 Wang S, Chen Y K, Zhou X J, et al. Materials Reports, 2024, 38(11), 247 (in Chinese). 王石, 陈昱恺, 周新甲, 等. 材料导报, 2024, 38(11), 247. 6 Wu Z J, Zhang L Y, Wang M, et al. Advanced Composites and Hybrid Materials, 2024, 8(1), 17. 7 Min J K, Jung Y J, Ahn J Y, et al. Advanced Materials, 2023, 35(52), e2211273. 8 Liu K Z, Han L, Tang P F, et al. Nano Letters, 2019, 19(12), 8343. 9 Kiran R G, Singh E, Hani U, et al. Journal of Controlled Release, 2023, 355, 709. 10 Rinoldi C, Lanzi M, Fiorelli R, et al. Biomacromolecules, 2021, 22(7), 3084. 11 Chen M H, Liu H, Chen X Y, et al. Applied Materials Today, 2024, 39, 102298. 12 Zhou Y, Wan C J, Yang Y S, et al. Advanced Functional Materials, 2019, 29(1), 1806220. 13 Slavin Y N, Asnis J, Häfeli U O, et al. Journal of Nanobiotechnology, 2017, 15(1), 65. 14 Yang Q, Chen R, Li M Z, et al. Advanced Functional Materials, 2024, 35(2), 2413080. 15 Zhang J, Yan K, Huang J R, et al. Advanced Functional Materials, 2024, 34(21), 2314433. 16 Wang S H, Yu L, Wang S S, et al. Nature Communications, 2022, 13(1), 3408. 17 Chen S X, Hang J R, Zhou Z X, et al. Industrial & Engineering Chemistry Research, 2021, 60(17), 6162. 18 Li J, Yu F, Chen G, et al. ACS Applied Materials & Interfaces, 2020, 12(2), 2023. 19 Ding Y H, Fu J, Xiong F Y, et al. Talanta, 2025, 282, 127004. 20 Wu W H, Yang K, Wu J, et al. Chemistry, 2025, 88(3), 241 (in Chinese). 吴文浩, 杨宽, 伍静, 等. 化学通报(中英文), 2025, 88(3), 241. 21 Sun J Y, Keplinger C, Whitesides G M, et al. Advanced Materials, 2014, 26(45), 7608. 22 Liu X T, Wu Z J, Jiang D W, et al. Advanced Composites and Hybrid Materials, 2022, 5(3), 1. 23 Li J H, Chen M J, Cheng S W, et al. Biomaterials, 2025, 315, 122958. 24 Asadikorayem M, Surman F, Weber P, et al. Advanced Healthcare Materials, 2024, 13(25), e2301831. 25 Wei L X, Yang Y, Qiu X Y, et al. Small, 2024, 20(50), e2405789. 26 Lee S Y, Lee Y, LeThi P, et al. Biomaterials Research, 2018, 22(1), 3. 27 Liu Y, Guo R, Wu T L, et al. Chemical Engineering Journal, 2021, 418, 129352. 28 Chen S, Huang J C, Wang H, et al. Chemical Engineering Journal, 2024, 501, 157589. 29 Jaramillo V, Arévalo D F, González-Hernández M, et al. Frontiers in Bioengineering and Biotechnology, 2024, 12, 1398052. 30 Chen L L, Wang W S, Lin Z F, et al. Journal of Nanobiotechnology, 2022, 20(1), 210. 31 Yang Z Z, You Y X, Liu X Y, et al. Journal of Nanobiotechnology, 2024, 22(1), 111. 32 Zhang Y, Li M, Wang Y C, et al. Bioactive Materials, 2023, 26, 323. 33 Zhu K, Jiang D W, Wang K, et al. Journal of Nanobiotechnology, 2022, 20(1), 211. 34 Choi C, Lee Y, Cho K W, et al. Accounts of Chemical Research, 2019, 52(1), 73. 35 Zhu S J, Yu C J, Liu N B, et al. Bioactive Materials, 2022, 13, 119. 36 Lopes P M P, Moldovan D, Fechete R, et al. Gels, 2022, 9(1), 18. 37 Deng J, Li J Y, Yan L Z, et al. International Journal of Biological Macromolecules, 2024, 278(P2), 134424. 38 McCoy T M, Turpin G, Teo B M, et al. Current Opinion in Colloid & Interface Science, 2019, 39, 98. 39 Cicuéndez M, Casarrubios L, Barroca N, et al. International Journal of Molecular Sciences, 2021, 22(13), 6701. 40 Jiang C X, Shi Q Z, Yang J, et al. Journal of Advanced Research, 2024, 63, 159. 41 Kaviani S, Talebi A, Labbaf S, et al. International Journal of Biological Macromolecules, 2024, 259, 129276. 42 Cao P L, Wang Y, Yang J, et al. Advanced Materials, 2024, 36(48), e2409632. 43 Liu L, Barber A H, Nuriel S, et al. Advanced Functional Materials, 2005, 15(6), 975. 44 Sun X, Qin Z H, Ye L, et al. Chemical Engineering Journal, 2020, 382, 122832. 45 Ye L J, Ji H C, Liu J, et al. Advanced Materials, 2021, 33(41), e2102981. 46 Wulf V, Bisker G. ACS Nano, 2024, 18(43), 29380. 47 Alvarez-Primo F, Anil K S, Manciu F S, et al. International Journal of Molecular Sciences, 2019, 20(19), 4802. 48 Xu L, Wang Y Y, Huang J, et al. Theranostics, 2020, 10(20), 8996. 49 Zheng Y K, Wei M, Wu H B, et al. Journal of Nanobiotechnology, 2022, 20(1), 328. 50 Huang H Y, Zhang X J, Dong Z C, et al. Journal of Colloid and Interface Science, 2022, 625, 817. 51 Wang C R, Jiang X, Kim H J, et al. Biomaterials, 2022, 285, 121479. 52 Peng L, An Y T, Xiang H J, et al. Nano Energy, 2024, 130, 110058. 53 Zheng Q Z, Chen C M, Liu Y, et al. International Journal of Nanomedicine, 2024, 19, 965. 54 Sattari S, Dadkhah T A, Adeli M. Polymers, 2018, 10(6), 660. 55 Baei P, Jalili-Firoozinezhad S, Rajabi-Zeleti S, et al. Materials Science and Engineering C, 2016, 63, 131. 56 Liang C Z, He J, Cao Y, et al. Journal of Biological Engineering, 2023, 17(1), 39. 57 Quan J X, Jiang X P, Ding T, et al. Chemical Engineering Journal, 2025, 503, 158320. 58 Liu D D, Bi S W, Wang H B, et al. Composites Part A, 2024, 180, 108065. 59 Zhang X K, Su Y, Xu J H, et al. Nano Energy, 2025, 133, 110484. 60 Yin J H, Pan S S, Guo X, et al. Nano-Micro Letters, 2021, 13(1), 30. 61 Yang C, Luo Y, Lin H, et al. ACS Nano. 2021, 15(1), 1086. 62 Ren D W, Zhang Y, Du B, et al. International Journal of Nanomedicine, 2024, 19, 4495. 63 Liu M X, Zheng L, Zha K K, et al. Frontiers in Bioengineering and Biotechnology, 2023, 11, 1308184. 64 Zhang Y F, Xu Z S, Li M K, et al. Device, 2024, 2(3), 100253. 65 Lu Y, He W N, Cao T, et al. Scientific Reports, 2014, 4(1), 5792. 66 Tu S, Tian T, Zhang J S, et al. ACS Nano, 2024, 18(51), 34829. 67 Bao B, Hao J R, Bian X J, et al. Advanced Materials, 2017, 29(44), 1702926. 68 Seike M, Uda M, Suzuki T, et al. ACS Omega, 2022, 7(15), 13010. 69 Kulkarni G, Guha Ray P, Sunka K C, et al. ACS Applied Materials & Interfaces, 2024, 16(42), 56762. 70 Xuan H Y, Wu S Y, Jin Y, et al. Advanced Science, 2023, 10(28), e2302519. 71 Ali A, Hussain F, Tahir M F, et al. Polymers, 2022, 14(7), 1289. 72 Wang C Y, Zhang J, Xu H, et al. Carbohydrate Polymers, 2022, 295, 119890. 73 Gan D L, Han L, Wang M H, et al. ACS Applied Materials & Interfaces, 2018, 10(42), 36218. 74 Qin H L, Liu P, Chen C R, et al. Nature Communications, 2021, 12(1), 4297. 75 Sheng Y J, Li Z H, Gao D M, et al. ACS Applied Materials & Interfaces, 2024, 16(46), 63840. 76 Xu J P, Wong C W, Hsu S H. Chemistry of Materials, 2020, 32(24), 10407. 77 Fanzio P, Chang C T, Skolimowski M, et al. Sensors, 2017, 17(5), 1169. 78 Carcione R, Pescosolido F, Montaina L, et al. Gels, 2023, 9(10), 784. 79 Song H, Wang Y F, Fei Q Y, et al. Exploration, 2022, 2(4), 20220006. 80 Liu R Q, Bi S W, Zhang L N, et al. Journal of Materials Chemistry B, 2024, 12(40), 10346. 81 Pan L J, Yu G H, Zhai D Y, et al. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(24), 9287. 82 Zhang Y, Tao Y L, Wang K Q, et al. Journal of Applied Polymer Science, 2021, 138(26), e50628. 83 Aizamddin M F, Mahat M M, Zainal A Z, et al. Polymers, 2022, 14(13), 2617. 84 Zhao X, Li P, Guo B L, et al. Acta Biomaterialia, 2015, 26, 236. 85 Guruge A G, Makki H, Troisi A. Journal of Materials Chemistry C, 2024, 12(47), 19245. 86 Won D, Kim J, Choi J, et al. Science Advances, 2022, 8(23), eabo3209. 87 Yao B W, Wang H Y, Zhou Q Q, et al. Advanced Materials, 2017, 29(28), 1700974. 88 Lu B Y, Yuk H, Lin S T, et al. Nature Communications, 2019, 10(1), 1043. 89 Li G, Huang K X, Deng J, et al. Advanced Materials, 2022, 34(15), e2200261. 90 Castrejón-Comas V, Mataró N, Resina L, et al. Carbohydrate Polymers, 2025, 348, 122941. 91 Furlani F, Montanari M, Sangiorgi N, et al. Biomaterials Science, 2022, 10(8), 2040. 92 Han Y, Sun M Y, Lu X C, et al. Composites Part B, 2024, 273, 111241. 93 Wu H Y, Xiao H, Zeng X D, et al. Materials Reports, 2024, 38(19), 242 (in Chinese). 伍红雨, 肖海, 曾向东, 等. 材料导报, 2024, 38(19), 242. |
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