基于Notch信号通路抑制剂的多功能血管支架涂层制备及表征

doi:10.11896/cldb.22120030

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Abstract Inflammatory reaction runs through the whole process of atherosclerosis (AS), and is highly related to a series of adverse events after vascular stent implantation, including in stent restenosis (ISR), late stent thrombosis (LST) and in stent neoatherosclerosis (ISNA) and so on. In many inflammatory diseases (including AS), Notch signaling pathway is abnormally activated. Therefore, the loading of Notch signaling pathway inhibitor (NSPI) is expected to reduce inflammation and then alleviate the complications of stent implantation. Herein, we proposed a modification strategy, using poly (lactic acid glycolic acid) copolymer (PLGA) as the carrier to load RO4929097, Notch signal pathway inhibitor, the surface of stent by ultrasonic atomization spraying to construct the NSPI/PLGA multi-functional vascular stent. The results show that NSPI/PLGA vascular stent can effectively release RO4929097 for up to 30 d, and can simultaneously inhibit inflammation, promote endothelial cell proliferation, anti-smooth muscle cell proliferation and anticoagulation. So this strategy has great potential in the field of interventional therapy.

Key words： atherosclerosis vascular stent inflammation Notch signaling pathway inhibitor ultrasonic atomization spraying surface modification

Published: 25 June 2024 Online: 2024-07-17

CLC number:

O647

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	Articles by authors
	JIN Leiyuan
	HU Fangkun
	JIANG Xiaojiao
	XIA Li
	LIU Ran
	XU Jiale
	TU Qiufen
	XIONG Kaiqin

Cite this article:

JIN Leiyuan,HU Fangkun,JIANG Xiaojiao, et al. Preparation and Characterization of Multifunctional Vascular Stent Coating Based on Notch Signal Pathway Inhibitor[J]. Materials Reports, 2024, 38(12): 22120030-8.

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http://www.mater-rep.com/EN/10.11896/cldb.22120030 OR http://www.mater-rep.com/EN/Y2024/V38/I12/22120030

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