利用NVP组分调控亲水增强型温敏性PNIPAAm共聚物

doi:10.11896/cldb.21100186

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Abstract Poly(N-isopropylacrylamide) (PNIPAAm) is one of the most widely studied and applied thermoresponsive polymers in biomedical fields. However, the temperature sensitivity of PNIPAAm homopolymers is relatively narrow, and the final products constructed from PNIPAAm homopolymers are difficult to change the overall volume or surface wettability under a wide temperature range by changing temperature, so their applications are limited. To expand the applications of PNIPAAm, it is necessary to design the thermoresponsive polymers with the adjustable lower critical solution temperature (LCST), especially for the enhanced LCST. Hence, hydrophilic N-vinylpyrrolidone (NVP) monomers were introduced into the molecular chains of thermoresponsive polymers, and P(NIPAAm-co-NVP) copolymers were polymerized and grafted onto the surfaces of platinum plates via the reactive groups of the copolymers to form copolymer films in this study. The results of attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), nuclear magnetic resonance (¹H-NMR) and gel permeation chromatography (GPC) showed that the copolymerization of each kind of monomer was carried out in predetermined way, and the participation rate of NVP in the polymerization process was significantly increased. Dynamic light scattering (DLS) and static contact angle data, scanning electron microscope (SEM) images confirmed that the LCST of P(NIPAAm-co-NVP) copolymers had been enhanced by addition of NVP moieties, so as to obtain thermoresponsive copolymer films with enhanced hydrophilicity, which could be used for drug controlled release and non-invasive cell harvest.

Key words： poly(N-isopropylacrylamide) (PNIPAAm) N-vinyl pyrrolidone (NVP) lower critical solution temperature (LCST) free radical polymerization hydrophilicity

Published: 10 August 2023 Online: 2023-08-07

CLC number:

O633

Fund:National Natural Science Foundation Youth Fund of China (21604034), General Program of Department of Education of Liaoning Province of China (LJKZ0693) and General Scientific Research Program of Department of Education of Liaoning Province of China (L2020015).

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	Articles by authors
	FAN Xiaoguang
	LEI Jingsheng
	GU Shiya
	LENG Xu
	LIU Chang
	YANG Lei

Cite this article:

FAN Xiaoguang,LEI Jingsheng,GU Shiya, et al. Regulation of Thermoresponsive PNIPAAm Copolymers with Enhanced Hydrophilicity via NVP Moieties[J]. Materials Reports, 2023, 37(15): 21100186-7.

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http://www.mater-rep.com/EN/10.11896/cldb.21100186 OR http://www.mater-rep.com/EN/Y2023/V37/I15/21100186

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