POLYMERS AND POLYMER MATRIX COMPOSITES |
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Biological Mesh: a Review |
ZHENG Xin1,2, DAN Weihua1,2,*, CHEN Yining1,2, LI Zhengjun1, DAN Ye3, HU Xiaobing3
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1 National Engineering Research Center for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China 2 Research Center of Biomedicine Engineering, Sichuan University, Chengdu 610065, China 3 School of Mechanical Engineering, Sichuan University, Chengdu 610065, China |
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Abstract The research of repair patch materials for human tissue defects remains a major focus of materials and biomedical engineering. Synthetic polymer patches are widely used in the clinic because of their good physical and mechanical properties, strong plasticity, and low price. Howe-ver, inherent issues, such as poor biocompatibility, poor ability to induce tissue regeneration, and various complications, have challenged their use. It is difficult to meet the clinical requirements of ideal repair materials for human tissue defects. Therefore, researchers have begun research on biological patch materials. Compared with a synthetic polymer patch, a biological patch has better biocompatibility and lower immunogenicity. Furthermore, it has good bio-assimilation with human tissue and induces the regeneration of new tissue, with less postoperative complications. However, there remain some issues with its practical application, including insufficient mechanical strength and a rapid degradation rate. To address these issues, a va-riety of approaches have been adopted, including the use of chemical crosslinking agents for crosslinking and fixation. In addition, a biomimetic strategy has been used for patch structural design and different patch forming methods have been adopted, such as electrospinning, to optimize the mesh structure. Moreover, a variety of composite materials can be used to maximize the physical and mechanical properties of patches, increasing their degradation resistance and biological properties. In this paper, the research progress on biological mesh materials is reviewed. The application status of biological patches in abdominal, myocardial, pelvic and urethral defects repair is also discussed, as well as the development prospect of biological patches.
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Published:
Online: 2022-10-26
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Fund:Fundamental Research Funds for the Central Universities(20826041C4159). |
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