静电纺纳米纤维基水凝胶伤口敷料的制备策略及应用研究进展

doi:10.11896/cldb.25010089

材料导报

2026, Vol. 40

Issue (1): 25010089-9 https://doi.org/10.11896/cldb.25010089

高分子与聚合物基复合材料

静电纺纳米纤维基水凝胶伤口敷料的制备策略及应用研究进展

侯可心¹, 刘建宏², 杨焜¹, 丁晟¹, 程雅丽¹, 王在玺¹, 李钒^1,*

1 军事科学院系统工程研究院,天津 300161
2 天津工业大学纺织科学与工程学院,天津 300387

Research Progress on the Preparation Strategies and Applications of Electrospun Nanofiber-based Hydrogel Wound Dressings

HOU Kexin¹, LIU Jianhong², YANG Kun¹, DING Sheng¹, CHENG Yali¹, WANG Zaixi¹, LI Fan^1,*

1 Systems Engineering Institute, Academy of Military Sciences, People's Liberation Army, Tianjin 300161, China
2 School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China

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摘要水凝胶因良好的亲水性、较高的溶胀率及三维多孔结构而成为一类具有潜力的湿性愈合伤口敷料。然而单纯使用水凝胶难以模拟细胞外基质中复杂的三维微纳米纤维结构,从而限制了其功能的提升和在伤口敷料领域的应用。近年来,静电纺纳米纤维基水凝胶伤口敷料结合了静电纺纳米纤维以及水凝胶的优势,展现出可定制的三维空间结构、大比表面积、高孔隙率,并且力学性能、生物功能性得到提升,拓展了水凝胶在伤口敷料领域的应用。本文综述了静电纺纳米纤维基水凝胶伤口敷料的制备策略,包括溶胶原位凝胶化法、静电喷涂法、层压法、分散法、3D打印法以及水凝胶直接静电纺丝法,讨论了其特点及在伤口敷料领域的应用,最后对该领域的未来研究方向做出总结及展望。

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关键词: 静电纺纳米纤维基水凝胶伤口敷料制备策略

Abstract: Hydrogels are a promising type of wound dressing due to their excellent hydrophilicity, high swelling rate, and three-dimensional porous structure. However, using pure hydrogels can lead to the limited functionality and application in wound dressings because of the difficulty of simulating the complex three-dimensional micro-nanofiber structure of the extracellular matrix. In recent years, electrospun nanofiber-based hydrogel wound dressings have combined the advantages of electrospun nanofibers and hydrogels, offering customizable three-dimensional spatial structures, large specific surface area, high porosity, enhanced mechanical properties, and improved biofunctionality, expanding their applications. This review summarizes the preparation strategies of electrospun nanofiber-based hydrogel wound dressings, including sol-gelatinization, electrostatic spraying, lamination, dispersion, 3D printing, and direct electrostatic spinning method. It then discusses their characteristics and applications, and finally summarizes and outlines the future research directions in this field.

Key words: electrospun nanofiber-based hydrogel wound dressings preparation strategy

出版日期: 2026-01-10 发布日期: 2026-01-09

ZTFLH:

TS106

基金资助: 研究院自主基金(ZZB2023C7010)

通讯作者: * 李钒,博士,高级工程师,研究方向为生物材料及其应用。vanadium_1981@163.com

作者简介: 侯可心,博士,工程师,研究方向为生物材料及其应用。

引用本文:

侯可心, 刘建宏, 杨焜, 丁晟, 程雅丽, 王在玺, 李钒. 静电纺纳米纤维基水凝胶伤口敷料的制备策略及应用研究进展[J]. 材料导报, 2026, 40(1): 25010089-9.
HOU Kexin. Research Progress on the Preparation Strategies and Applications of Electrospun Nanofiber-based Hydrogel Wound Dressings. Materials Reports, 2026, 40(1): 25010089-9.

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https://www.mater-rep.com/CN/10.11896/cldb.25010089 或 https://www.mater-rep.com/CN/Y2026/V40/I1/25010089

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