可生物降解壳聚糖半互穿网络水凝胶的制备及胃滞留应用

doi:10.11896/cldb.24040064

材料导报

2025, Vol. 39

Issue (8): 24040064-9 https://doi.org/10.11896/cldb.24040064

高分子与聚合物基复合材料

可生物降解壳聚糖半互穿网络水凝胶的制备及胃滞留应用

董沛^1,2, 刘宇欣³, 张鹏^1,2, 盛扬^1,2, 孙一新^1,2, MarkBradley^2,4, 张嵘^1,2,*

1 常州大学材料科学与工程学院,江苏常州 213164
2 常州大学先进功能材料江苏省国际合作联合实验室,江苏常州 213164
3 常州华森医疗器械股份有限公司,江苏常州 213164
4 伦敦玛丽女王大学,大学精准医疗研究院,英国伦敦 E1 1HH

Preparation of Biodegradable Chitosan Semi-interpenetrating Network Hydrogel and Its Application for Gastric Retention

DONG Pei^1,2, LIU Yuxin³, ZHANG Peng^1,2, SHENG Yang^1,2, SUN Yixin^1,2, Mark Bradley^2,4, ZHANG Rong^1,2,*

1 School of Materials Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, China
2 Advanced Functional Materials of Jiangsu Joint Laboratory for International Cooperation, Changzhou University, Changzhou 213164, Jiangsu, China
3 Changzhou Waston Medical Equipment Co., Ltd., Changzhou 213164, Jiangsu, China
4 Precision Healthcare University Research Institute, Queen Mary University of London, London E1 1HH, UK

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摘要胃滞留水凝胶是一种具有潜在减肥效果的材料,可有效解决口服药物疗法中药物生物利用度低的问题。本工作旨在开发一种可降解的水凝胶,且其能够长时间滞留在胃部,起到药物释放的效果。本工作合成了两种可降解大分子交联剂,以丙烯酰胺为主要单体,将其与壳聚糖溶液混合,通过氧化还原引发剂引发聚合后形成具有半互穿网络结构的可降解水凝胶。通过扫描电子显微镜和傅里叶变换红外光谱等分析手段,对所制备的水凝胶的形貌和化学结构进行了表征。体外药物释放实验表明,该壳聚糖半互穿网络水凝胶能够实现可控的药物释放,延长药物在胃内的滞留时间。本工作还评估了水凝胶的溶胀性能、生物相容性和在模拟胃液中的降解性能,结果显示该水凝胶(交联剂比例4∶6)的溶胀率达到2 700%,对L-929细胞具有良好的生物相容性,在模拟胃液中5 d失重达到7%。4∶6水凝胶在60%变形情况下的压缩模量大于13 kPa,能够耐受胃部蠕动挤压。因此,基于丙烯酰胺的壳聚糖半互穿网络水凝胶在胃部疾病治疗方面具有潜在的应用前景。

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关键词: 可降解水凝胶胃滞留药物缓释生物相容性半互穿网络

Abstract: Gastric retention hydrogels represent a potential material with weight-loss effects and offer an effective solution to address the low bioavailability of drugs in pharmaceutical therapy. This study aims to develop a degradable hydrogel capable of prolonged retention in the stomach, facilitating both weight loss and drug release. Two degradable macromolecular cross-linking agents were synthesized, with acrylamide as the main mo-nomer, mixed with chitosan solution for the preparation of a degradable hydrogel with a semi-interpenetrating network (sIPN) structure initiated by a redox initiator. The morphology and chemical structure of the prepared hydrogels were characterized using analytical techniques such as SEM and FTIR. In vitro drug release experiments demonstrated that the hydrogel achieved controlled drug release, extending the drug's retention time in the stomach. The swelling performance, biocompatibility and degradation properties of the hydrogel in simulated gastric fluid (SGF) were also evaluated. Results indicated that the hydrogel with cross-linking agent ratio 4∶6 exhibited a swelling ratio of 2 700%, excellent biocompatibility and a weight loss of 7% in SGF over 5 days. The 4∶6 hydrogel had a compressive modulus greater than 13 kPa at 60% deformation, demonstrating resistance to gastric peristalsis. Therefore, the chitosan sIPN hydrogel holds promising potential for applications in weight loss and the treatment of gastric diseases.

Key words: degradable hydrogel gastric retention drug release biocompatibility semi-interpenetrating network

出版日期: 2025-04-25 发布日期: 2025-04-18

ZTFLH:

TB324

基金资助: 江苏省六大人才高峰创新团队(SWYY-CXTD-001);常州市科技局国际合作项目(CZ20190019)

通讯作者: 张嵘,博士,常州大学材料科学与工程学院教授、江苏省特聘教授。目前主要从事聚合物微点阵列芯片的制备与应用;(干)细胞的分离、提纯与体外培养相关聚合物的开发;可生物降解聚合物材料的开发;抗/灭菌聚合物材料的研发;生物医用高分子材料的研发。rzhang@cczu.edu.cn

作者简介: 董沛,常州大学材料科学与工程学院硕士研究生,在张嵘教授的指导下进行研究。目前主要研究领域为亲水交联剂和可降解半互穿网络壳聚糖水凝胶的制备及水凝胶在胃滞留方面的应用。

引用本文:

董沛, 刘宇欣, 张鹏, 盛扬, 孙一新, MarkBradley, 张嵘. 可生物降解壳聚糖半互穿网络水凝胶的制备及胃滞留应用[J]. 材料导报, 2025, 39(8): 24040064-9.
DONG Pei, LIU Yuxin, ZHANG Peng, SHENG Yang, SUN Yixin, Mark Bradley, ZHANG Rong. Preparation of Biodegradable Chitosan Semi-interpenetrating Network Hydrogel and Its Application for Gastric Retention. Materials Reports, 2025, 39(8): 24040064-9.

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https://www.mater-rep.com/CN/10.11896/cldb.24040064 或 https://www.mater-rep.com/CN/Y2025/V39/I8/24040064

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