Regulation of Thermoresponsive PNIPAAm Copolymers with Enhanced Hydrophilicity via NVP Moieties
FAN Xiaoguang1, LEI Jingsheng1, GU Shiya1, LENG Xu1, LIU Chang1, YANG Lei2,*
1 College of Engineering, Shenyang Agricultural University, Shenyang 110866, China 2 School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun 113001, Liaoning, China
Abstract: Poly(N-isopropylacrylamide) (PNIPAAm) is one of the most widely studied and applied thermoresponsive polymers in biomedical fields. However, the temperature sensitivity of PNIPAAm homopolymers is relatively narrow, and the final products constructed from PNIPAAm homopolymers are difficult to change the overall volume or surface wettability under a wide temperature range by changing temperature, so their applications are limited. To expand the applications of PNIPAAm, it is necessary to design the thermoresponsive polymers with the adjustable lower critical solution temperature (LCST), especially for the enhanced LCST. Hence, hydrophilic N-vinylpyrrolidone (NVP) monomers were introduced into the molecular chains of thermoresponsive polymers, and P(NIPAAm-co-NVP) copolymers were polymerized and grafted onto the surfaces of platinum plates via the reactive groups of the copolymers to form copolymer films in this study. The results of attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), nuclear magnetic resonance (1H-NMR) and gel permeation chromatography (GPC) showed that the copolymerization of each kind of monomer was carried out in predetermined way, and the participation rate of NVP in the polymerization process was significantly increased. Dynamic light scattering (DLS) and static contact angle data, scanning electron microscope (SEM) images confirmed that the LCST of P(NIPAAm-co-NVP) copolymers had been enhanced by addition of NVP moieties, so as to obtain thermoresponsive copolymer films with enhanced hydrophilicity, which could be used for drug controlled release and non-invasive cell harvest.
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2023, Vol. 37 
