| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Construction and Study of Pancreaticojejunal Anastomotic Stents with Surface Micropatterns |
| JIAN Qiongyi1, WANG Yilei2, JIANG Zherui3, GUO Qianru2, ZHANG Hao4, LI Kezhou1,4,*
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1 College of Medicine, Southwest Jiaotong University, Chengdu 610031, China
2 School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
3 School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
4 Department of Pancreatic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China |
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Abstract Pancreatic fistula after pancreaticoduodenectomy greatly affects the postoperative survival rate and quality of life of patients. At present, thermoplastic polyurethane elastomer rubber (TPU) tube is clinically selected as the pancreaticojejunal anastomotic stent to cope with this complication. However, there are problems such as mismatching specifications and easily falling off. In this work, a novel pancreaticojejunal anastomotic stent was made with biodegradable materials. Inspired by the micropatterns on the surface of tree frog toe pads to enhance wet friction, three kinds of micropatterns were designed to be modified on the surface of the stent, and the properties were compared. Using 6-arm polyethylene glycol as an initiator, ring-opening polymerization was performed with ε-caprolactone, and acryloyl chloride was added to connect the double bond. The 6a PEG-PCL stent for pancreaticojejunal anastomosis crosslinked by light was prepared by using shape memory properties of the material. We evaluated shape-memory performance, mechanical properties, and hydrophilicity of the 6a PEG-PCL stent. It is proved that the stent had good shape memory performance. And this stent is rigid enough to provide effective support for the pancreatic duct. It can drain pancreatic juice and maintain the patency of the pancreatic duct. The friction behavior between the stent and the pancreatic duct tissue was simulated. The results showed that the 6a PEG-PCL stent modified by surface micropatterns had greater wet friction than the TPU stent and caused less wear to the pancreatic duct tissue. It is showed that the regular hexagonal pillar micropattern was the best choice for surface modification. Finally, we evaluated the biocompatibility of the material and the safety of the material was confirmed. Therefore, 6a PEG-PCL stent had potential clinical application value.
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Published: 10 October 2023
Online: 2023-09-28
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| Fund:Key Research and Development Projects in Sichuan Province (2020YFS0261). |
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2023, Vol. 37 
