一步法制备PLA/PDA/Ag多孔抗菌纳米纤维膜及其<br/>促进伤口愈合作用研究

doi:10.11896/cldb.23080053

Abstract
Figure/Table
References
Related Citation (15)

Download:

Full Text ( PDF ) (6190KB)
Export: BibTeX | EndNote (RIS)

Abstract Effective control the irregular flow of wound biological fluid and prevention of wound infection remain significant challenges in promoting wound healing and skin regeneration. In this study, a PLA/PDA/Ag nanofibrous membrane with exudate adsorption, wound antibacterial and mechanical properties was prepared by a one-step method of ‘electrospinning + in-situ crosslinking’. After testing the chemical composition, internal structure and mechanical properties of the fibrous membrane, it was used in antibacteria and wound healing experiments to verify the practical application on wound healing. The results showed that the water absorption of PLA/PDA/Ag fibrous membrane can reached 65.0% and the water contact angle is 72.35°, which can contribute to the obvious adsorption and diversion effect on the wound exudate. The diameter of inhibition zones of S.ureus and E.coli were (25.4±0.6) mm and (28.7±0.9) mm, respectively when treated with the PLA/PDA/Ag fibrous membrane. The skin wound healing of mice reached 95.3% on the 9th day after treated with the membrane, with no infection occurred, and the wound contraction rate was significantly better than that of the control. The hydrophilicity, antibacterial property and stretchability of the PLA/PDA/Ag fibrous membrane prepared in this study can be adjusted by the addition ratio of DA, and then be used in different wound fields, which has certain application prospects in the field of wound accessory design.

Key words： electrospinning anti-bacteria fiber silver nanoparticle wound healing

Published: 25 September 2023 Online: 2023-09-18

CLC number:	TQ340.64
	R318.08

Fund:National Natural Science Foundation of China (52062025), the Gansu Provincial Science and Technology Program Grant (22YF7NA149, 22CX8GA062), and Gansu Provincial Education Department Innovation Fund Project (2022A-032).

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TENG Guixiang
	YANG Yifan
	HOU Sutong
	YAO Hui
	ZHANG Chun

Cite this article:

TENG Guixiang,YANG Yifan,HOU Sutong, et al. Preparation of PLA/PDA/Ag Porous Antibacterial Nanofibrous Membrane by One-step and Their Effect on Promoting Wound Healing[J]. Materials Reports, 2023, 37(18): 23080053-6.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.23080053 OR http://www.mater-rep.com/EN/Y2023/V37/I18/23080053

1 Fan Y, Lu Q, Liang W, et al. European Polymer Journal, 2021, 157, 110619.
2 Shi L, Liu X, Wang W, et al. Advanced Materials, 2019, 31(5), 1804187.
3 Wang C H,Li M L, Bi X C, et al. Journal of Textile Research, 2021, 42(5), 16 (in Chinese).
王春红, 李明龙, 碧旋才, 等. 纺织学报, 2021, 42(5), 16.
4 Zhang D, Zhang N, Ma F, et al. Journal of Hazardous Materials, 2018, 360, 150.
5 Chen Z, Cui K Y, Zhang W Y. Materials Reports, 2023, 37(Z1), 22100086-1 (in Chinese).
陈卓, 崔科洋, 张文宇, 等. 材料导报, 2023, 37(Z1), 22100086-1.
6 Zhao X J. Modification of bacterial cellulose with polydopamine/polyethyleneimine for antibacterial and wound healing application.Master's Thesis, Tianjin University of Science and Technology, China, 2021 (in Chinese).
赵翔军. 细菌纤维素/聚多巴胺/聚乙烯亚胺复合材料的抗菌及伤口愈合研究. 硕士学位论文, 天津科技大学, 2021年.
7 Khamrai M, Banerjee S L, Pau S, et al. ACS Sustainable Chemistry & Engineering, 2019, 7(14), 12083.
8 Park J, Brust T F, Lee H J, et al. ACS Nano, 2014, 8(4), 3347.
9 Liu M Y, Zeng G J, Wang K, et al. Nanoscale, 2016, 8(38), 16819.
10 Zhang Z, Zhang J, Zhang B L, et al. Nanoscale, 2013, 5(1), 118.
11 Ku S H, Park C B. Biomaterials, 2010, 31(36), 9431.
12 Zhang C, Gu Y, Teng G, et al. ACS Applied Materials & Interfaces, 2020, 12(26), 29883.
13 Wu Z, Zhou W, Deng W, et al. ACS Applied Materials & Interfaces, 2020, 12(18), 20307.
14 Naraginti S, Kumari P L, Das R K, et al. Materials Science and Engineering C, 2016, 62, 293.
15 Zhang M, Zhang X, He X, et al. Nanoscale, 2012, 4, 3141.
16 Sr A, Mr B, Sz C, et al. European Polymer Journal, 2021, 157, 110635.
17 Gama e Silva G L, de Bustamante M S S, Dias M L, et al. Arabian Journal of Chemistry, 2023, 16, 104392.
18 Song K, Hao Y, Liu Y, et al. Carbohydrate Polymers, 2023, 300, 120272.
19 Guo Y, Ghobeira R, Sun Z, et al. Polymer, 2022, 262, 125502.
20 Han G, Cai J, Liu C, et al. Applied Surface Science, 2020, 541, 148566.
21 Zhang Q, Wang Y, Zhang W, et al. Colloids and surfaces B: Biointerfa-ces, 2019, 184, 110506.
22 Alippilakkotte S, Kumar S, Sreejith L. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 529, 771.
23 Sharifabad S S, Derazkola H A, Esfandyar M, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2021, 118, 104455.
24 Ouda M, Ibrahim Y, Kallem P, et al. Journal of Cleaner Production, 2022, 330, 129871.
25 Shen W, Ao F, Ge X, et al. Materials Today Communications, 2022, 30, 103093.
26 Chankaew C, Somsri S, Tapala W, et al. Particuology, 2018, 40, 160.
27 Wang Q, Zhou S, Wang L, et al. Composites Part B Engineering, 2021, 224, 109165.
28 Yang L, Han Z, Chen C, et al. Materials Science and Engineering C, 2020, 117, 111265.