包载荧光共轭聚合物的阳离子聚合物纳米微球的合成及协同抗菌效果研究

doi:10.11896/cldb.22010234

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Abstract As drug-resistant bacteria infection become increasingly serious recently, pursuing new antibacterial strategies and developing more effective antibacterial materials have become an important task. This work provided a new antibacterial method combining photodynamic and cationic antibacterial mechanism. The fluorescent nanospheres were successfully prepared by microemulsion polymerization using N-isopropylacrylamide (NIPAM) and methylacryloyloxyethyltrimethyl ammonium chloride (DMC) as monomers, loaded with a fluorescent conjugated polymer (FCP). The composition, particle size distribution and micro-morphology of the microspheres were analyzed, and their ability to produce singlet oxygen was tested. The fluorescent nanospheres were used to study the antibacterial activity of E.coli, S. aureus and methicillin resistant Staphylococcus aureus (MRSA). The results indicated that the cationic antibacterial mechanism was dominated when the mass concentration of nanospheres was high (≥ 0.05 mg/mL). When the mass concentration was low (≤ 0.01 mg/mL), photodynamic antibacteria activity contributed primarily to the total antibacterial ability of nanospheres. For the nanospheres with m(NIPAM)∶m(DMC) = 1∶3, the sterilization rate of both E.coli and S. aureus reached over 95% after 30 min of illumination when the concentration of nanospheres was 0.01 mg/mL. For the nanospheres with m(NIPAM)∶m(DMC) = 1∶1, the synergistic sterilization rate of MRSA was the highest when the concentration of nanospheres was 0.05 mg/mL. Cytotoxicity assay showed that the nanospheres had good biocompatibility when the mass concentration was lower than 0.1 mg/mL. Therefore, the fluorescent nanospheres can effectively combine cationic and photodynamic antibacterial functions, develop an excellent synergistic antibacterial ability, and are expected to provide support for the solution to the drug-resistant bacterial infection.

Key words： photodynamic antibacterial ammonium cationic polymer nano-microsphere fluorescent conjugated polymer drug-resistant bacteria

Published: 25 July 2023 Online: 2023-07-24

CLC number:

O631

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	Articles by authors
	JIANG Zunyu
	SHENG Yang
	SUN Yixin
	LI Jian
	Mark Bradley
	ZHANG Rong

Cite this article:

JIANG Zunyu,SHENG Yang,SUN Yixin, et al. Synthesis and Synergistic Antibacterial Activity of Cationic Polymer Fluorescent Nanoparticles Loaded with Fluorescent Conjugated Polymer[J]. Materials Reports, 2023, 37(14): 22010234-9.

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http://www.mater-rep.com/EN/10.11896/cldb.22010234 OR http://www.mater-rep.com/EN/Y2023/V37/I14/22010234

1 Fang M, Zheng X, Gu J F. Foreign Medical Antibiotics, 2011, 32(6), 253(in Chinese).
房咪, 郑珩, 顾觉奋. 国外医药抗生素分册, 2011, 32(6), 253.
2 Zhang D, Zhao Y, Gao Y, et al. Journal of Materials Chemistry B, 2013, 1(8), 5100.
3 Shao W, Liu H, Liu H, et al. RSC Advances, 2015, 5(12), 4795.
4 Zuo H J, Wen W H, Wu D C, et al. Progress in Chemical Industry, 2013, 32(3), 604(in Chinese).
左华江, 温婉华, 吴丁财, 等. 化工进展, 2013, 32(3), 604.
5 Ongwae G M, Morrison K R, Allen R A, et al. ACS Infectious Diseases, 2020, 6(6), 1427.
6 Ji W H, Koepsel R R, Murata H, et al. Biomacromolecules, 2017, 18(8), 2583.
7 Wang Y, Chen R, Li T, et al. Industrial & Engineering Chemistry Research, 2019, 59(1), 458.
8 Liang J S, Zeng J M, Li J J, et al. Advances in Chemistry, 2019, 31(9), 1263(in Chinese).
梁敬时, 曾佳铭, 李俊杰, 等. 化学进展, 2019, 31(9), 1263.
9 Garciadiaz M, Huang Y Y, Hamblin M R. Methods, 2016, 109, 158.
10 Khosravi A D, Rostamian J, Moradinegad P. Journal of Medical Sciences, 2008, 8(6), 57.
11 Meeker D G, Jenkins S V, Miller E K, et al. ACS Infectious Diseases, 2016, 2(4), 241.
12 Xu Q L, He P, Wang J W, et al. Dyes and Pigments, 2019, 160, 519.
13 Chu X H, Zhang P, Wang Y L, et al. Carbon, 2021, 176, 126.
14 Yuan Q, Tang Y L. Chinese Science:Chemistry, 2022(1), 14(in Chinese).
袁琼, 唐艳丽. 中国科学:化学, 2022(1), 14.
15 Chen B B, Mi H, Gao S, et al. Journal of Chemical Engineering of Chinese Universities, 2015, 29(4), 252 (in Chinese).
陈彬彬, 米衡, 高山, 等. 高校化学工程学报, 2015, 29(4), 252.
16 Wang G R, Duan Z Q, Sheng Y, et al. Chemical Communications Journal, 2016, 52(69), 10521.
17 Sheng Y, Duan Z Q, Z, Jia Z, et al. ACS Applied Bio Materials, 2018, 1, 888.
18 Liu L L, Sheng Y, Sun Y X, et al. New Materials for Chemical Industry, 2021, 49(6), 112(in Chinese).
刘丽丽, 盛扬, 孙一新, 等. 化工新型材料, 2021, 49(6), 112.
19 Entradas T, Waldron S, Volk M. Journal of Photochemistry and Photo-biology B:Biology, 2020, 204, 111787.
20 Li H, Gong M, Xiao J, et al. Chemical Engineering Journal, 2022, 429, 132600.