金属阳离子掺杂对羟基磷灰石微球性能的影响

doi:10.11896/cldb.20100280

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Abstract Metal ion doping can give hydroxyapatite unique properties, such as magnetism, antibacterial property, bone inductivity, etc. The millimeter-scale hydroxyapatite-sodium alginate (HA-SA) composite microspheres were made by pneumatic extrusion printing, and cross-linked by divalent metal cations (Ca, Sr, Cu and Zn). The effect of different ion doping on the properties of microspheres (macro and micro structure, physical and chemical properties, and biological properties) was studied in detail. The results show that there are some differences in the effect of different ion doping on the performance of HA. These four inos have little effect on the macroscopic morphology of the microspheres, but the presence of Cu and Zn promote the decomposition of HA into β-TCP during the sintering process, leading to the increase of the degradation rate of the microspheres. The antibacterial rate of 5% Cu-HA-1200 and 5% Zn-HA-1200 microspheres are significantly higher than 5% Ca-HA-1200 and 5% Sr-HA-1200. HA/β-TCP biphasic spheroid is obtained in this research and these spheroids may be beneficial for bone defect repair.

Key words： hydroxyapatite metal cation doping pneumatic extrusion printing sintering

Published: 10 April 2023 Online: 2023-04-07

CLC number:

TB321

Fund:National Natural Science Foundation of China (32001017,51665036, 31960207).

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	LI Shuiyuan
	XU Zhenyu
	LI Ke
	ZHOU Kui

Cite this article:

LI Shuiyuan,XU Zhenyu,LI Ke, et al. Effect of Metal Cation Doping on Properties of Hydroxyapatite Microspheres[J]. Materials Reports, 2023, 37(7): 20100280-7.

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http://www.mater-rep.com/EN/10.11896/cldb.20100280 OR http://www.mater-rep.com/EN/Y2023/V37/I7/20100280

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