基于硅气凝胶包载尼莫地平新型载药系统的构建及胃肠稳定性研究

doi:10.11896/cldb.21030015

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Abstract Nimodipine is an effective drug for the treatment of cardiovascular and cerebrovascular diseases. However, its low solubility and poor stability greatly limit its development and utilization. Thus it becomes an urgent problem of how to effectively improve the solubility and stability of nimodipine. The purpose of this study was to construct a novel drug delivery system consisting of nimodipine coated with silicon aerogel. In order to explore its drug release properties and gastrointestinal stability, the silicon aerogels before and after drug loading were characterized and analyzed by X-ray diffraction, N₂ adsorption-desorption and thermogravimetric techniques. The results showed that the drug loading capacity of the new drug delivery system based on silicon aerogel was up to 31.24%, and the skeleton structure of the system was not damaged after drug loading. Compared with nimodipine, the new drug delivery system significantly improved the release rate of nimodipine in gastric and intestinal fluid in vitro. At the same time, nimodipine loaded by silica aerogel could be retained in stomach, large intestine and small intestine for 4 h, and its stability was significantly improved. The new drug delivery system has good drug release performance and gastrointestinal stability, which provides a new choice and data basis for further development of nimodipine oral preparation.

Key words： silica aerogel nimodipine drug release performance drug delivery system stability

Published: Online: 2023-03-27

CLC number:

TQ4

Fund:2019 Harbin University of Commerce ‘Young Innovative Talents' Support Project (2019CX41,2019CX12), National Innovation and Entrepreneurship Training Program for College Students (202010240019), Undergraduate Teaching Leading Talent Training Program of Harbin University of Commerce (201902), and Harbin University of Commerce Doctoral Research Initiation Fund (13DL023).

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	Articles by authors
	LYU Chunyan
	LIU Yang
	ZHANG Wenjun
	WANG Qing

Cite this article:

LYU Chunyan,LIU Yang,ZHANG Wenjun, et al. Preparation and Gastrointestinal Stability of Nimodipine Drug Delivery System Based on Silica Aerogel[J]. Materials Reports, 2023, 37(6): 21030015-6.

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http://www.mater-rep.com/EN/10.11896/cldb.21030015 OR http://www.mater-rep.com/EN/Y2023/V37/I6/21030015

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