介孔硅止血材料的研究现状及应用前景

doi:10.11896/cldb.21010168

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Abstract Uncontrolled bleeding is an important cause of traumatic death in wartime and peacetime. The research on hemostatic materials is a hot issue in the field of pre-hospital first aid. The pre-hospital hemostatic materials have high requirements in terms of hemostatic rate, environmental adaptability and biological safety. The existing polymer and inorganic hemostatic materials often have the problems of unstable performance, poor environmental adaptability, high cost and potential safety risks. Mesoporous silica with a similar microstructure to zeolite is one of the most potential inorganic hemostatic materials, which is extremely suitable for pre-hospital emergency hemostasis, according to its good biocompatibility and environmental adaptability, porous structure and high specific surface area, adjustable pore size and composition, and facile surface modification.
Mesoporous silica materials are mainly constructed by molecular self-assembly, and hydrothermal or solvothermal synthesis is the most typical preparation technology. There are also studies on microwave radiation synthesis or ultrasonic synthesis to prepare mesoporous silica, which could shorten the preparation time and reduce the cost. The pore-forming template agent in the precursor should be removed in the preparation process of mesoporous silica, and the inorganic framework structure be retained to form an ordered porous microstructure. The removal of the template is the key to the synthesis of mesoporous silica, usually including high-temperature calcination, solvent extraction, supercritical fluid extraction, microwave heating, and so on. It was shown that the larger the pore size of mesoporous silicon material, the better the blood coagulation effect and the more obvious the cell differentiation promoting function is. Therefore, the pore expansion technology is expected to improve the hemostatic properties of mesoporous silica materials. In addition, mesoporous silica could be compounded with metal ions, functional drugs and organic polymers, achieving various functions, such as antibacterial and promoting healing. The morphology, composition and surface modification of the mesoporous silica have a certain influence on its biosafety. The biosafety of the mesoporous silica can be optimized by material design and functional modifications to enhance its operability and practicability in the pre-hospital emergency.
This article reviews the rapid synthesis method of mesoporous silica, introduces the method of template removal, pore size control and function diversification during the preparation of mesoporous hemostatic materials, discusses the problem of biosafety of mesoporous silica as a hemosta-tic material. The preparation trend of porous silica materials and the prospects of future hemostatic applications are prospected.

Key words： mesoporous silica hemostatic material synthesis biological safety

Published: Online: 2022-12-09

CLC number:

R318.08

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	Articles by authors
	ZHANG Zhuoran
	LI Fan
	HOU Min
	ZHANG Yuanyuan
	DING Sheng
	WEI Xiaohui
	LIN Song

Cite this article:

ZHANG Zhuoran,LI Fan,HOU Min, et al. Development of Mesoporous Silica Hemostatic Materials and Their Application Prospects[J]. Materials Reports, 2022, 36(23): 21010168-9.

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http://www.mater-rep.com/EN/10.11896/cldb.21010168 OR http://www.mater-rep.com/EN/Y2022/V36/I23/21010168

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