Zn<sup>2+</sup>交联海藻酸钠抑菌缓释微球制备及其抑菌效应

doi:10.11896/cldb.21020040

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Abstract To improve the utilization of potassium diformate (KDF) in gastrointestinal tract, this study, which was based on the single factor experiment, optimized the design data by response surface methodology. The KDF microspheres were prepared by Zn²⁺ cross-linked sodium alginate (ALG). The obtained microspheres were systematically characterized by chemical structure, morphology and thermal properties, and the sustained-release antibacterial properties of the microspheres were tested. The results showed that the optimal formulation of microspheres was the concentration of ALG was 1.5% (mass fraction, the same below), the concentration of ZnSO₄was 7.0%, and the surfactant was 0.8 mL. In vitro slow-release properties of microspheres showed that the release time was prolonged to 6 h in the intestinal tract, and the release mechanism followed the first-order kinetic model and Ritger-Peppas model, which significantly slowed down the release rate of KDF. In addition, when the concentration of microspheres was 96 mg/mL, the bacteriostatic rates against Escherichia coli, Staphylococcus aureus and Bacillus subtilis were 88%, 87% and 67%, respectively. It effectively inhibits the overreproduction of bacteria and it was a potential new antimicrobial agent which could be widely used in livestock feeding.

Key words： potassium diformate response surface methodology Zn²⁺cross-linked microspheres release mechanism bacteriostatic rate

Published: Online: 2022-04-07

CLC number:

TB321

Fund:National Natural Science Foundation of China (51564008, 51978189), Research Funds of the Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control (1801K002).

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	Articles by authors
	LI Yuyan
	YANG Zhongxin
	CHEN Nanchun
	MO Shengpeng
	WANG Xiuli
	XIE Qinglin

Cite this article:

LI Yuyan,YANG Zhongxin,CHEN Nanchun, et al. Preparation and Antibacterial Effect of Zn²⁺ Crosslinked Alginate Slow-release Microspheres[J]. Materials Reports, 2022, 36(7): 21020040-7.

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http://www.mater-rep.com/EN/10.11896/cldb.21020040 OR http://www.mater-rep.com/EN/Y2022/V36/I7/21020040

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