声化学法制备巯基壳聚糖/黄芪油微胶囊

doi:10.11896/cldb.21010096

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Abstract Traditional Chinese herb has attracted extensive attention due to its good efficacy, low toxicity and low side effects. However, some active ingredient extracts are relatively sensitive to external influence and lose their effectiveness. Microcapsules, as a new type of drug delivery carrier, can encapsulate drugs and improve the bioavailability. After several decades of development, microcapsules can be prepared through many synthetic methods. But there are some problems to be solved, such as the complicated preparation process, the introduction of harmful substances, etc. Compared with conventional microencapsulation methods, sonochemistry is simple, green and efficient. In this paper, Chitosan as raw material and 2-iminothiane hydrochloride as sulf hydrylation reagent were used to prepare thiolated chitosan (TC). Using TC as the shell and astragalus membranaceus oil (AM) as the core, we therefore obtained TC/AM core-shell microcapsules by sonochemistry. The effects of thiol content and pH value on the synthetic reaction were investigated. The optimal degree of thiolation and pH value were determined through energy spectrometer (EDS), laser confocal scanning microscope (CLSM), dynamic light scatterer (DLS), etc. The results showed that the optimal mass ratio of chitosan and thiolation reagent was 5∶1, and the pH value was 6.0. The particle size of TC/AM microcapsules prepared under the optimal condition were characterized by DLS and consequently was 962.4 nm.

Key words： chitosan astragalus membranaceus oil microcapsules sonochemical method

Published: 25 March 2022 Online: 2022-03-21

CLC number:

O636.1

Fund:Ningxia Key R & D Program (2018BEB04036) and the National Key Laboratory Open Project (SKLPME2017-4-11).

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	Articles by authors
	GUO Shengwei
	WANG Xin
	XUE Min
	LI Dan
	WANG Guxia

Cite this article:

GUO Shengwei,WANG Xin,XUE Min, et al. Preparation of Thiolated Chitosan (TC)/Astragalus Membranaceus Oil (AM) Microcapsules by Sonochemical Method[J]. Materials Reports, 2022, 36(6): 21010096-5.

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http://www.mater-rep.com/EN/10.11896/cldb.21010096 OR http://www.mater-rep.com/EN/Y2022/V36/I6/21010096

1 Wang X, Guo S, Zhou Y, et al. ChemistrySelect, 2020, 5, 5072.
2 Alkan C, Sari A, Karaipekli A, et al. Solar Energy Materials and Solar Cells, 2009, 93(1), 143.
3 Cui X, Wang B, Zhong S, et al. Colloid and Polymer Science, 2013, 291(10), 2271.
4 Cui X, Guan X, Zhong S, et al. Ultrasonics Sonochemistry, 2017, 38, 145.
5 Avivi S, Nitzan Y, Dror R, et al. Journal of the American Chemical So-ciety, 2003, 125(51), 15712.
6 Drozdek S, Bazylińska U. Colloid and Polymer Science, 2016, 294(1), 225.
7 Shi Y, Li Q, Li R Y, et al. Food and Fermentation Industries, 2015, 41(1), 80 (in Chinese).
石燕, 李倩, 李如一, 等. 食品与发酵工业, 2015, 41(1), 80.
8 Gao H Y, Li J W, Chen Z Z. Biotechworld, 2015(2), 184 (in Chinese).
高合意, 李晋文, 陈正珍. 生物技术世界, 2015(2), 184.
9 Gedanken A. Chemistry-A European Journal, 2008, 14(13), 3840.
10 Zhang R, Liu X, Ji H B. Progress in Chemistry, 2017, 30(1), 29 (in Chinese).
张瑞, 刘璇, 纪红兵. 化学进展, 2017, 30(1), 29.
11 Li Z, Wang Z, Du X, et al. Advanced Healthcare Materials, 2018, 7(11), 1701326.
12 Grinberg O, Hayun M, Sredni B, et al. Ultrasonics Sonochemistry, 2007, 14(5), 661.
13 Skirtenko N, Tzanov T, Gedanken A, et al. Chemistry-A European Journal, 2010, 16(2), 562.
14 Han Y, Radziuk D, Shchukin D, et al. Macromolecular Rapid Communications, 2008, 29(14), 1203.
15 Xia H, Wang Q. Chemistry of Materials, 2002, 14(5), 2158.
16 Xia H, Wang Q. Journal of Applied Polymer Science, 2003, 87(11), 1811.
17 Skirtenko N, Tzanov T, Gedanken A, et al. Chemistry-A European Journal, 2010, 16(2), 562.
18 Lian H. The construction and evaluation of oral drug delivery system based on functional thiolated polymeric micelles. Master's Thesis, Doctorate Dissertation of Shenyang Pharmaceutical University, China, 2014 (in Chinese).
廉鹤. 功能性巯基化聚合物胶束口服药物传递系统的构建与评价. 硕士学位论文, 沈阳药科大学, 2014.
19 Croisier F, Jérôme C. European Polymer Journal, 2013, 49(4), 780.
20 Wang K L. Preparation of sulfhydryl chitosan derivatives and the nature research. Master's Thesis, University of Jinan, China,2013 (in Chinese).
王凯丽. 巯基壳聚糖衍生物的制备及其性能研究. 硕士学位论文, 济南大学, 2013.