Materials Reports  2021, Vol. 35 Issue (z2): 516-519 |
| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Spinnability of Collagen-acetic Acid Mixing Solution and Mechanical Properties of Electrospinning Nanofiber Membrane Evaluation |
| CHEN Weiying, CHEN Zhenyong, YANG Zaijun, SHI Feng, LI Yunxiang
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| Collaboration Innovation Center for Tissue Repair Material Engineering Technology,College of Life Science, China West Normal University, Nanchong 637009, China |
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Abstract Collagen have good absorbability and biocompatibility, thus it is widely used in biomedicine. However, the application of collagen nanofiber membrane from electrospinning technique is restricted in biomedical field, for its lower mechanical strength. In this study, the spinnability of type I collagen mixing solution with acetic acid was studied, and the mechanical properties of collagen nanofiber membrane were measured. The results showed that the collagen nanofiber membranes obtained by 10% mixed solution using 40% acetic acid were smooth. The average diameter of the fibers was (305.19±119.67) nm, and the layers of fibers were clear and created a continuous crossed net. The elastic modulus of the collagen nanofiber membrane of 0.2 mm was (749.22±107.72) MPa, and the average maximum tensile strength was (21.92±3.03) N. This indicated that collagen nanofiber membrane of 0.2 mm had good mechanical properties. The collagen nanofiber membrane from mixed solution of acetic acid/collagen has good appearance and mechanical strength. It can provide materials for further cell experiments, and be developed into medical patch materials, which can meet different clinical needs and have the value of practical application.
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Published: 09 December 2021
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| Fund:This work was financially supported by the Major Cultivation Project of Sichuan Provincial Department of Education (14CZ0015), and the Meritocracy Research Funds of China West Normal University (17YC321, 17YC322). |
About author:: Weiying Chen is currently an associate professor of China West Normal University. She received her Ph.D. degree from Chengdu Institute of Biology, Chinese Academy of Sciences in 2013. Her research interests are plant genetics and cell biology, and the development of biomedical products such as animal collagen electrospinning. She has published more than 20 papers in domestic and foreign academic journals.
Yunxiang Li is a professor and master supervisor of West China Normal University, and the doctoral supervisor of Sichuan Agricultural University. He is also the dean of College of Environmental Science and Enginee-ring, director of Sichuan Collaborative Innovation Center for Tissue Repair Materials Engineering Technology, and vice president Ecological Society of Sichuan. His team's research interests are plant ecology, medicinal botany, environmental impact assessment, curriculum and teaching theory, and so on. |
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