角膜接触镜的聚羧酸甜菜碱表面改性研究

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Abstract Currently, more and more people use contact lenses because of the multiple advantages including less affection by wet weather, a wider field of vision, elegant personal appearance, etc. However, protein adsorption on the surface of contact lenses can cause a series of adverse effects, such as reduced vision, inflammatory complications, and increased discomfort. In order to address this issue, carboxylic acid betaine was grafted to the surface of silicone hydrogel-based contact lenses via surface-initiated atom transfer radical polymerization. The successful surface grafting was confirmed by contact angle measurement, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). Due to the outstanding biocompatibility of poly(carboxylic acid betaine), the contact lenses after surface modification exhibited excellent resistance to protein adsorption and bacterial adhesion. Moreover, this method shows great potential in surface modification of contact lenses.

Key words： contact lenses biocompatibility surface modification atom transfer radical polymerization antifouling

Published: 09 December 2021

CLC number:

TQ314

Fund:This work was financially supported by the Medical Science and Technology Project of Zhejiang Province(2019PY020)and the Project of Philosophy and Social Science Planning in Zhejiang Province(19NDJC068YB).

About author:: Jie Yu obtained her master's degree in ophthalmology from Zhejiang Univresity. She is now an associate chief physician in the department of ophthalmology in Zhejiang Provincial People's Hospital. She works on the clinic medical work of ophthalmology for more than ten years. Her mainly clinical and research interest focuses on the therapy of xerophthalmia, myopia, amblyopia, and asthenopia.
Lan Zhang, who graduated from Shanxi Medical University in June 2008 has a master's degree in ophthalmology. In the same year she joined the department of ophthalmology in Zhejiang Provincial People's hospital and work so far. She mainly engaged in optometry and fundus medical work.

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Cite this article:

YU Jie,ZHAO Hailan,ZHANG Lan. Surface Modification of Contact Lenses with Biocompatible Polymers Enables Anti-fouling Surface[J]. Materials Reports, 2021, 35(z2): 488-491.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2021/V35/Iz2/488

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