金属有机骨架材料固定化酶的研究进展

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Abstract The traditional immobilization matrices for enzymes have limitations of uncontrollable pore size distribution, high cost, leaching of enzymes, and poor stability. Metal-organic frameworks (MOFs) are considered as a new class of solid supports for enzyme immobilization due to their intrinsic properties, such as high surface area and pore volume, tunable pore size and structure, and chemical and thermal stability. Firstly, this review summarizes the preparation strategies for enzyme immobilization in MOF materials by the following two major categories, postsynthetic packaging and de novo encapsulation (biomimetic mineralization, co-precipitation, and mechanochemical encapsulation). Secondly, it introduces the design strategies of hierarchically porous MOFs for enzyme immobilization, which enable the achievement of high enzyme loading and the improvement of substrate diffusion rate. Thirdly, it introduces some advances on multienzyme systems in MOFs and biomimetic MOFs with enzyme-like activity for enzyme immobilization. The special pore structure of MOFs can greatly shorten the diffusion distance between enzyme and substrate, make full use of the intermediate products of enzyme cascade reaction, and therefore could significantly improve the catalytic activity of enzyme. Finally, the main applications of MOF-enzyme composites in biosensing and catalytic removal of pollutants are summarized, and some bottleneck problems are put forward to provide reference for the further research and future industrialization of MOF-enzyme composites.

Key words： metal-organic frameworks (MOFs) enzyme immobilization hierarchically pore structure cascade reaction biosensing pollutant catalysis

Published: 09 December 2021

CLC number:

O641.4

Fund:This work was financially supported by the National Natural Science Foundation of China (21777119).

About author:: Ran Xu received her Ph. D. in 2004 from the National University of Singapore. She has been an Associate Professor and Master's Supervisor at Tongji University and State Key Laboratory of Pollution Control and Resource Reuse. Her research interests are water treatment technology and green functional materials for environmental applications. She has published more than 70 papers on some international or national Journals, such as Journal of Environmental Quality, Chemical Engineering Journal, ACS Applied Materials and Interfaces, Bioresource Technology and Journal of Tongji University (Natural Science), presided many national and provincial research projects, won several Ministerial and Provincial-Level Science and Technology Awards, authorized 13 patents.
Yinan Wu received his Ph.D. in 2012 from Tongji University. He has been an Associate Professor and Ph.D.'s Supervisor at Tongji University and State Key Laboratory of Pollution Control and Resource Reuse. His research interests are rooted in preparation and application of hierarchically porous materials and green synthesis of metal-organic frameworks for environmental-related applications. He has published more than 50 papers on Angewandte Chemie-International Edition, Small, Chemical Communications, Journal of Hazardous Materials and so on, presided several national and provincial research projects, authorized 6 invention patents.

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Cite this article:

XU Ran,LI Zhihui,WU Yinan, et al. Research Advances in Enzyme Immobilization on Metal-organic Frameworks[J]. Materials Reports, 2021, 35(z2): 285-293.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2021/V35/Iz2/285

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