图案化与生物功能化聚3,4-乙烯二氧噻吩生物界面

doi:10.11896/cldb.20080232

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Abstract This study demonstrates that functionalized poly(3,4-ethylenedioxythiophenes) (PEDOTs) with tunable protein/cell interactions and low impedance are applied to fabricate the patterned bio-platform for spatially guiding cell attachment. These functionalized PEDOTs copolymers are prepared by electropolymerized an antifouling EDOT bearing phosphorylcholine (EDOT-PC) and conjugatable EDOT bearing carboxyl acid (EDOT-COOH) into the copolymers. We investigate electrochemical impedance, anti-protein/cell attachment for different composition of the PEDOT copolymers. The specific cell-adhesion on the copolymer surfaces is achieved through grafting RGD peptide on the PEDOTs. Furthermore, we fabricate cell-attachment and cell-repellent micro-patterned PEDOT platforms with different widths by photolithography and electrochemical deposition techniques, the platforms can spatially guide cell attachment effectively, which make it possible for investigating cell behavior. This PEDOT platforms have the potential for tissue repair/regeneration.

Key words： poly(3,4-ethylenedioxythiophene) phosphorylcholine carboxyl acid micropattern

Published: 12 November 2021

CLC number:

TQ317

Fund:National Natural Science Foundation of China (21474014).

Corresponding Authors: halin@shu.edu.cn; bozhu@shu.edu.cn

About author:: Yaqiong Zhang, Ph.D. candidate of Science in Mate-rials Physics and Chemistry, Donghua University.
Hsing-An Lin, professor of Shanghai University. He has forced on the study of stimuli-responsive conjugated polymers, pi-conjugated molecules, and functionalized polyaromatic hydrocarbons.
Bo Zhu, professor of Shanghai University. He works on the functional conducting polymers, electro-responsive polymers, fiber reinforced composites, flexible bioelectronics, wearable and wireless sensors.

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	ZHANG Yaqiong
	LIN Hsing-An
	PAN Qichao
	QIAN Sihao
	ZHANG Shuhua
	QIU Gao
	ZHU Bo

Cite this article:

ZHANG Yaqiong,LIN Hsing-An,PAN Qichao, et al. Patterned and Biofunctionalized Poly(3,4-ethylenedioxythiophene) Interfaces[J]. Materials Reports, 2021, 35(20): 20183-20189.

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http://www.mater-rep.com/EN/10.11896/cldb.20080232 OR http://www.mater-rep.com/EN/Y2021/V35/I20/20183

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