Materials Reports  2020, Vol. 34 Issue (Z2): 501-506 |
| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Preparation and Antifungal Properties of Self-assembled Amphiphilic Chitosan Nanocapsules |
| HE Zuyu1, XIE Jianghui1, LI Puwang1, QU Yunhui2, YANG Ziming1, YU Lijuan2, WANG Chao1, LIU Yunhao1, YAO Quansheng1, ZHOU Chuang1
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1 Key Laboratory of Hainan Province for Postharvest Physiology and Technology of Tropical Horticultural Products, South Subtropical Crop Research Institute of China Academy of Tropical Agricultural Sciences, Zhanjiang 524091,China
2 Agricultural Product Processing Research Institute of Yunnan Academy of Agricultural Sciences, Kunming 650000, China |
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Abstract In this paper, eleostearic acid (EA) and N-acetyl-L-cysteine (NAC) were grafted to the chain of chitosan (CS) to prepare an amphiphilic chitosan derivative (CS-g-EA-NAC), and the chemical structure of CS-g-EA-NAC was characterized by Fourier transform infrared (FT-IR) and 1H nuclear magnetic resonance (1H NMR). Then, CS-g-EA-NAC based nanoparticles were prepared by ultrasonic self-assembly method, and the spinosad (SSD) loaded nanocapsules (SSD@CS-g-EA-NAC) were spherical in shape with a uniform particle size distribution, and the average particle size was about 520 nm. In vitro release revealed that the SSD@CS-g-EA-NAC nanocapsules exhibited a sustained and pH-responsive drug release property. Finally, the antifungal properties of SSD@CS-g-EA-NAC and SSD against Fusarium oxysporum were determined by the growth rate method. The results showed that the half effective concentration (EC50) of SSD@CS-g-EA-NAC and SSD against Fusarium oxysporum was were 29.05 μg/mL and 42.05 μg/mL, respectively, indicating that the virulence of SSD@CS-g-EA-NAC is higher than that of free SSD, and the conjugate CS-g-EA-NAC is conducive to improve the virulence of SSD. This research can provide a theoretical basis for the construction of chitosan-based drug delivery system.
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Published: 08 January 2021
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| Fund:This work was financially supported by Hainan Provincial Natural Science Foundation of China (219QN294), Guangdong Basic and Applied Basic Research Foundation (2019A1515010714), Yunnan Province Academician Expert Workstation (202005AF150007), the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (1630122017009, 1630122020004), Special Fund for Guangdong Modern Agricultural Industry Technology System Innovation Team Construction Specific Foundation (2019KJ140), Guangdong Agricultural Science and Technology Innovation System Management Project Foundation (0835-190Z22404211C1) and the Science and Technology Projects of Zhanjiang (2018A02015). |
| About author:: Zuyu He, received his M.S. degrees in June 2018 from South China Agricultural University in engineering. He is currently a research intern in South Subtropical Crops Research Institute of Chinese Academy of Tropical Agricultural Sciences, and mainly engaged in the microencapsulation of natural polymer materials and their application in drug carriers. He has published 8 articles in domestic and foreign journals and declared 6 invention patents. Chuang Zhou received his M.S. degrees in June 2017 from South China Agricultural University in engineering. He is currently an assistant researcher in South Subtro-pical Crops Research Institute of Chinese Academy of Tropical Agricultural Sciences, and mainly engaged in the research of bio-based drug-loaded nanomaterials, and has published more than 10 articles in important domestic and foreign journals and declared 8 invention patents. |
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