Materials Reports  2020, Vol. 34 Issue (Z1): 63-65 |
| INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
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| One-step Synthesis of Strontium-doped Porous Hydroxyapatite Microspheres |
| QI Meili1,2,3, MEI Fengce1, HUANG Hao1, CUI Fengkun1
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1 School of Traffic and Civil Engineering, Shandong Jiaotong University, Ji'nan 250357, China;
2 School of Materials Science and Engineering, Shandong University, Ji'nan 250061, China;
3 Shandong Branden Medical Devices Co., Ltd, Qihe 251100, China |
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Abstract Hydroxyapatite (HA) porous microspheres have excellent biological properties and fluid ability. They are widely used as bone filling materials and drug sustained-release carriers, showing a promising development prospect. Strontium-doped HA shows stronger osteogenic differentiation activity and improves the degradability of HA, however, how to obtain silver-doped porous HA microspheres with a large size is a big challenge. In this paper, strontium-doped porous HA microspheres was synthesized via hydrothermal homogeneous precipitation method with the aqueous solution of SrCl2·6H2O and (NH4)2HPO4 as raw materials, urea as the pH regulator, and L-glutamic acid (Glu) as the growth regulator. Research were focused on effects of the amount of strontium ion doping on the phase and microstructure of the obtained products, in order to provide experimental basis for the preparation of ion doped porous HA microspheres. Results show that strontium ion doped porous HA microspheres with spherical and uniform morphology exist under the conditions of n(Sr)/n(Sr+Ca)=0.01 and hydrothermal treatment at 180 ℃ for 10 h.
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Published: 01 July 2020
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| Fund:This work was financially supported by the National Natural Science Foundation of China (11947117), the China Postdoctoral Science Foundation (2019M660164) and the Doctoral Scientific Research Foundation of Shandong Jiaotong University (BS50004919). |
| About author:: Meili Qi received her D.S. degrees in June 2018 from Shandong University in engineering. Since Jan 2020, she starts to do postdoctoral research at Shandong University and Shandong Branden Medical Devices Co., Ltd., focusing on the research of biomedical materials ; Fengkun Cui obtained his D.S. degrees in June 2018 from Chang'an University in engineering. In 2016, he went to the City University of New York for joint docto-ral training with the support of the China Scholarship Council. He was appointed to the faculty upon graduation, and is currently a lecturer of Shandong Jiaotong University. Currently, he is selected for the minister of science and technology of “North Frozen Sea Long Bridge Construction and Maintenance Laboratory” in Shandong Provincial Communications Department, the expert of online ser-vice capacity of network freight in Shandong province, and the reviewer of international academic journals such as Engineering Structures and Structure and Infrastructure Engineering. He has presided over and participated in more than 10 science and technology projects and horizontal projects of the Ministry of Communications, Shandong province and Jiangsu province. Besides, he has published more than 30 academic papers (more than 10 indexed by SCI/EI) and obtained more than 10 national patents. His main research directions are the basic theory of long-span bridge structure and the analysis of mechanical properties of new materials. |
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