Materials Reports  2019, Vol. 33 Issue (Z2): 533-537 |
| POLYMERS AND POLYMER MATRIX COMPOSITES |
|
|
|
|
|
| Preparation and Characterization of Sericin/Hydroxyapatite/PolycaprolactoneComposite Scaffold Materials |
| FANG Yan, XU Shui, WU Tingfang, ZHU Yong
|
| College of Biotechnology,Laboratory of Fiber Materials of Southwest University, Chongqing 400715 |
|
|
|
|
Abstract Based on good performance in the application of biomaterial, sericin, hydroxyapatite and polycaprolactone were used to prepare a new type of tissue engineering material via twice lyophilisation. In the experiment, the physical and chemical properties of sericin/hydroxyapatite/polycarprolactone composite scaffold material were studied first; then the morphology of this material was investigated; finally, biocompatibility of this material was evaluated. The results show that the composites have good forming effect, uniform pore distribution and porosity of more than 50%, and the sericin molecules exhibit β-sheet structure. With the increasing proportion of PCL in the composite scaffold material, the thermal decomposition temperature of the material increase, its performance improved, the elastic modulus of the material gradually increased, indicating PCL has played a role in enhancing the rigidity of the stent material. Cytotoxicity test results show that cells grow well, the composite material is non-toxic and harmless.
|
|
Published: 25 November 2019
|
|
|
| Fund:This work was financially supported by 2017 Chongqing Silkworm Mulberry Industry Development Subsidy Fund Project (CQ2017CSE010). |
About author:: Yan Fang, 2012—2016, undergraduate of Hexi college, 2016—2019, master’s degree in biotechnology college, Southwest University, majors in silk biology.
Yong Zhu, Professor,Doctoral tutor, Young and middle-aged experts with outstanding contributions at the ministerial level. 1978—1982, Southwest Agricultural University undergraduate, 1982—1985, Southwest Agricultural University graduate student, 2000—2005, Southwest Agricultural University doctoral student, from 1998 to now, Southwest University professor. Mainly engaged in genetic breeding of silkworm, Bombyx mori important mutant gene development and utilization. Breeding of the new varieties of Silkworm Spring “Day 3x 5.6” promotion
more than 500,000 boxes, more than 20 million yuan to create benefits, the summer and autumn with a new variety of “Xia Fang x Qiu Bai” Through the provincial identification, has now become Zhongqing and Sichuan Province, the most major silkworm varieties, the annual promotional volume in more than 1 million boxes, the new increase in economic benefits of 30 million yuan, 1996 won the first prize of Chongqing Science and Technology Progress. Presided over the breeding of a family of high quality silkworm varieties “Yu Silkworm 1th”, 2006 won the third prize of Zhongqing Technology Progress. Published 7 representative papers in important academic journals at home and abroad. |
|
|
1 陈忠敏,陈枭,庞亚妮,等.丝绸,2015,52(4),25.
2 Li Min, Zou Can, An Hongzhan,et al. Metal Materials and Metallurgy Engineering,2012,40(6),55.
3 张琦,浦益琼,王冰,等.中成药,2015,37(12),2722.
4 王琳婷,杨明英,朱良均,等.蚕业科学,2010,36(4),639.
5 杨延慧,严涵,康晓梅,等.化工新型材料,2011,39(12),13.
6 王飞.木质素聚己内酯降解塑料的制备及性能研究.硕士学位论文,西南科技大学,2015.
7 李海滨.聚(ε-己内酯)/丝胶蛋白纳米纤维支架的制备及细胞相容性研究.硕士学位论文,重庆大学,2010.
8 Wang Linting, Yang Mingying,Zhu Liangjun, et al. Science of Sericultrue,2010,36(4),639.
9 肖肖,陈昌盛,刘伟强,等.化学进展,2017(5),513. |
|
|
|
渝公网安备50019002502923号 © Editorial Office of Materials Reports.
