碳量子点作为生物相容性发光材料在再生医学方面的应用

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Abstract Carbon nanomaterials (CNMs) have attracted the attention of the scientific community because of their role in electronic, optical, thermal and mechanical properties and multi-purpose functional chemistry. Because of their inherent hydrophobicity, carbon nanomaterials have more biocompatibility and safety than metal-based nanomaterials. Carbon nanomaterials (CNMs) can be used as an efficient drug delivery platform by hydrophobic interaction or π-π stacking. In recent years, graphene, fullerene, carbon nanotubes and carbon quantum dots have become the most widely used carbon nanomaterials for the treatment of cancer and intracellular labeling. These carbon nanomaterials can be biocompatible by covalent or non-covalent modification. Covalent modification is the introduction of hydroxyl, carboxy or amino groups on its surface. These free radicals further bind to the protective biopolymer polyethylene glycol (PEG), while the non-covalent modification is supported on CNMs. These carbon-based nanomaterials have been proved to be not only good loading carriers for various biological macromolecules, but also good photosensitizers. In addition, many ideal functionalization can be integrated into CNMs for active targeting and homing of tumors. Because of the inhe-rent optical properties of CNMs, many researchers have also studied its application in tumor cell and stem cell imaging, and proved that they are reliable materials in future biological imaging.
Among many carbon-based nanomaterials, carbon quantum dots (CQDs) have not only attracted people’s attention in the field of materials but also attracted great interest in biological applications because of their special zero-dimensional structure and excellent properties. In the past decade, the development of biological macromolecules such as genes, growth factors and other biological macromolecules to stem cells has led to the exploration of the possibility of improving the treatment of human diseases through nano-drug therapy. However, although great progress has been made, many key technical problems need to be solved before this nanodrug therapy can be used safely and effectively in the clinical environment. For example, after transplantation of stem cells to ischemic area, due to the change of microenvironment, the survival and migration of stem cells are monitored.
In this paper, the progress of these nanodrug therapy is reviewed, with emphasis on the advanced carbon quantum dot nanoparticles technology to monitor the position of stem cells in vivo and in vitro after therapeutic transplantation, as well as the tracer and manipulation of macromolecules in living cells.

Key words： carbon quantum dots stem cell nano-particle tracking

Published: 25 November 2019

CLC number:	R318.08
	R329.2

About author:: Lei Yang master of Cardiovascular Surgery, Renji Hospital, Affiliated Renji Hospital of Shanghai Jiao Tong University School of Medicine, is now in the second grade of master’s degree. The main research direction is to control stem cells of nano-materials, and to repair the cardiac muscle after myocardial regeneration and ischemia-reperfusion.
Feng Lian chief physician, deputy director of cardiovascular surgery, graduate tutor of Shanghai Jiaotong University, member of cardiothoracic vascular surgery of Chinese Medical Association, associate member of Chinese physician, member of Youth Union of Renji Hospital. He received a bachelor’s degree in medicine in 1994 and began cardiothoracic surgery. He received a master’s degree from Medical College of Shanghai Jiaotong University in 2000 and a doctorate from Medical College of Shanghai Jiaotong University in 2003. In the same year, he was awarded the Shanghai Baosteel Education Award and went to Mary Hospital of the University of Hong Kong (China) to study at Mary Hospital of the University of Hong Kong. In 2006, he was selected into the “100-person Program”
of the School of Medicine of Shanghai Jiaotong University and studied at Cleveland Medical Center, the No. 1 heart center in the United States. From March 2007 to March 2008, he majored in clinical work in cardiac surgery at San Maaru Hospital affiliated to the National Pavia University of Italy, majoring in coronary artery bypass grafting and valve surgery. Congenital heart di-sease and minimally invasive heart surgery, participated in a variety of heart surgery (including various minimally invasive minimally invasive heart surgery, da Vinci robot surgery, heart transplantation, lung transplantation, etc.) nearly 500 sets, coronary artery bypass grafting and other heart surgery nearly 100 sets, returned home to obtain the certificate of study abroad issued by the Ministry of Education of China.

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Cite this article:

YANG Lei,YANG Zhi,LIAN Feng. Application of Carbon Quantum Dots as Biocompatible Luminous Materials in Regenerative Medicine[J]. Materials Reports, 2019, 33(Z2): 1-9.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2019/V33/IZ2/1

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