模拟人体皮肤湿度响应特征和力学性质的皮肤模型

doi:10.11896/cldb.18090279

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Abstract High-quality artificial skin model (ASM) plays a critical role in developing skin contacted materials, accordingly, the great efforts have been paid in the research of ASM. In this study, an artificial skin model was constructed by chitosan (CTS) hydrogel and polydimethylsiloxane (PDMS), aiming at simulating the humidity response and mechanical properties of human skin. Furthermore, the impact of the mass ratio of CTS and PDMS, and the content of curing agent on the performance of ASM were investigated. It was found that the increase of curing agent content contributed to the raise of hydration level and swelling rate of the ASM. The prepared ASM would well simulated diverse hydration degrees of human skin with mass ratio of the curing agent to the polydimethylsiloxane of less than 1∶20. The results of UST test indicated that the reduction of curing agent content would lead to the decline of elastic modulus of ASM. When the mass ratio of curing agent and PDMS was reduced to 1∶50, the ASM exhibited similar variation behaviors of elastic modulus to depth with human skin in inner forearm. Additionally, the elastic modulus of dry ASM was higher than that of wet ASM, which was consistent with the characteristics of human skin.

Key words： artificial skin model elastic modulus water swelling rate hydration

Published: 16 September 2019

CLC number:

TB332

Fund:This work was financially supported by the Shanghai Natural Science Foundation (17ZR1442100), the Shanghai Municipal “Science and Technology Innovation Action Plan” International Cooperation Project (15540723600).

About author:: Jingmin Chenreceived his M.S. degrees in June 2018 from Shanghai University in engineering. From May 2017 to June 2019, he co-educated and learned at the Shanghai Advanced Research Institute, focusing on the research of biomimetic material.
Xiangqiong Zengreceived her Master degree in Applied Chemistry in 2003 and Ph.D. degree in Material Science in 2006 from Shanghai Jiao Tong University. Then, she worked at Johnson & Johnson consumer group during 2006—2010 as staff scientist on Skin Care technology. From 2011—2015, she was appointed as a tenure track assistant professor at the University of Twente, working on skin tribology. Currently, she is a full professor at Shanghai Advanced Research Institute, Chinese Academy of Sciences. Her research interests are functional interface materials for biotribology and aqueous lubrication, including active control of friction and wear by surface and interface design of skin contacting materials and medical devices, by test methodology development with the design of instrument and bio-inspired human tissue model, and by additive and emulsion development for aqueous lubrication.

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	CHEN Jingmin
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Cite this article:

CHEN Jingmin,LI Jiusheng,CHEN Jinyang, et al. A Skin Model Simulating Humidity Response Features and Mechanical Properties of Human Skin[J]. Materials Reports, 2019, 33(22): 3829-3832.

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http://www.mater-rep.com/EN/10.11896/cldb.18090279 OR http://www.mater-rep.com/EN/Y2019/V33/I22/3829

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