近红外二区光声成像造影剂的研究进展

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Abstract Photoacoustic imaging (PAI) is an emerging hybrid imaging technique that combines the high sensitivity of optical imaging with the deep penetration and high spatial resolution of acoustic imaging. It has great potential in the field of bio-imaging and has been developed rapidly in recent years. PAI is based on the photoacoustic effect, and the ultrasonic waves generated by imaging object after laser irradiation is used for imaging. PAI working in the second near-infrared window (NIR-II) takes the advantages of deeper penetration, lower background noise, and higher maximum permissible exposure when compared to the first near-infrared window (NIR-I), which leads to high-resolution imaging of deep tissues. The exogenous PAI contrast agents can enhance imaging contrast by locally enhance tissue absorption performance and photoacoustic signals. Therefore, exogenous PAI contrast agents working in NIR-II region are crucial for realizing deep tissue PAI, and has attracted much attention in recent years.
However, most of the reported PAI contrast agents working in NIR-I region, including inorganic nanomaterials and small organic molecules, have limited penetration depth and obvious background noise. Reports related PAI in NIR-II region are very limited since the lack of exogenous PAI contrast agents with NIR-II absorption and photoacoustic conversion capabilities. On the other hand, the short of mature and stable PAI system working in NIR-II region also hinders the development of PAI.
In this paper, the progress of PAI contrast agents working in NIR-II region was summarized, including organic semiconducting conjugated polymers, inorganic nanomaterials and small molecule organic dyes. The synthesis methods, absorption properties and PAI performance were introduced. The future development of PAI in NIR-II region was prospected.

Key words： organic semiconducting conjugated polymers inorganic nanomaterials small molecule organic dyes photoacoustic imaging contrast agents second near-infrared window

Published: 05 July 2019

CLC number:

R445

About author:: Ke Gao, is currently pursuing his master degree at the School of Materials Science and Engineering & State Key Laboratory of Metal Matrix Composites of Shanghai Jiao Tong University under the supervision of Prof. Wanwan Li. His research has focused on the application of nanomaterials in tumor imaging and therapy.Wanwan Li obtained his Ph.D. in materials science from Shanghai University of China in 2004, then he joined the School of Materials Science and Engineering & State Key Lab of Metal Matrix Composites of Shanghai Jiao Tong University (SJTU) in 2005, where he was promoted to a professor in 2013. He is currently a professor and doctoral supervisor of the SJTU. His research concerns fabrication of inorganic nanocrystals, organic-inorganic hierarchical assemblies, and their applications on biomedical diagnosis & therapy. He has published more than 50 articles in scientific peer-reviewed international journals.

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Cite this article:

GAO Ke,LI Wanwan. Research Progress on Photoacoustic Imaging Contrast Agents Working in the Second Near-infrared Window[J]. Materials Reports, 2019, 33(z1): 481-484.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2019/V33/Iz1/481

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