碳纳米材料的抗菌性及在生物医学中的应用研究进展

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Abstract As the main antibacterial agents used in clinic, antibiotics provide a simple and effective treatment for some infectious diseases of human. However, the overuse and abuse of antibiotics gradually lead to the emergence of super resistant bacteria, which makes bacterial infection more and more difficult to treat, and poses a serious threat to human health. At present, the bacterial infection caused by drug-resistant bacteria has been a serious challenge to the global public health. Therefore, it is imperative to develop new materials/drugs that have antibacterial effect and are not easy to produce drug resistance.
Rapid advances in nanotechnology have provided promising options for antimicrobial therapy over the past decade. By studying the mechanism of interaction between nanomaterials and bacteria, it is found that nanomaterials are less likely to induce bacterial resistance than traditional anti-biotics. According to the different sources of materials, nano-antibacterial materials are mainly divided into natural, organic and inorganic systems. Natural systems include plant and animal source, which can not realize mass production because of the restriction of safety, production and other factors. Due to their poor stability and weak antibacterial effect, organic systems are greatly restricted in use. At present, the inorganic systems are mainly dominated by silver-based antibacterial agents. In addition to being easily oxidized and agglomerated, their biological safety is still controversial.
Under this background, carbon nanomaterials have attracted much attention due to their wide range of raw materials, special structural characteristics, physical and chemical properties, and relatively good biocompatibility. The carbon nanomaterials introduced in this paper mainly include carbon nanotubes, graphene materials, carbon dots and their derivatives, which are widely used at present. The existing research results show that carbon nanomaterials have high antibacterial activity and are not easy to produce drug resistance, and have been gradually applied in the field of antibacterial.
In this paper, the characteristics and antibacterial mechanism of carbon nanomaterials are reviewed. The application status of carbon nanomaterials in the field of medical antibacterial is introduced, and the application prospect of carbon nanomaterials in medical catheter is prospected,which can provide a reference for solving urinary tract infections associated with catheters.

Key words： drug-resistance bacteria carbon nanomaterials antibacterial medical application

Published: 01 July 2020

CLC number:

TB34

Fund:This work was financially supported by the Shanxi Provincial Key Research and Development Projects (201703D32015-4),Shanxi Provincial Excellent Talents Science and Technology Innovation Project (201805D211001)

About author:: Chao Zhang graduated from Shanxi Medical University in July 2018 with a bachelor's degree in clinical medicine. He is a postgraduate student of Bethune hospital affiliated to Shanxi Medical University, conducting research under the guidance of professor Zhang Li and Yang Yongzhen. The main research field is the application of carbon nanomaterials in antibacterial catheters ; Li Zhang, the deputy chief physician and the master tutor of Bethune Hospital of Shanxi Province. He received his master's degree from Shanxi Medical University in July 2001 and his Ph.D. degree from Taiyuan University of Technology in November 2012.In recent years, many papers have been published in the field of antibacterial nanomaterials and antibacterial catheters, and has undertaken six projects, and won 3 national invention patents, 3 utility model patents.

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	ZHANG Chao
	ZHANG Li
	LIU Xinghua
	CHEN Lin
	YANG Yongzhen
	YU Shiping

Cite this article:

ZHANG Chao,ZHANG Li,LIU Xinghua, et al. Research Advances in Antibacterial Properties and Applications in Biomedicine of Carbon Nanomaterials[J]. Materials Reports, 2020, 34(Z1): 53-57.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2020/V34/IZ1/53

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