pH响应型纳米药物用于化疗-光热协同治疗肿瘤

doi:10.11896/cldb.21120187

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Abstract Chemotherapy (CT) combined with photothermal therapy (PTT) is an effective combination for the treatment of tumor. Herein, we deve-loped a subcellular-targeted NIR-responsive nanomedicine Fe₃O₄@PDA-TPP/S₂-PEG-hyd-DOX (abbreviated as Fe₃O₄-ATSPD) as a new photothermal agent, the intracellular uptake of which can be enhanced by magnetic targeting. Under the near-infrared (NIR) irradiation, the photothermal effect can be realized from the polydopamine photosensitizer, leading to a dramatic decrease in mitochondrial membrane potential. Simultaneously, the conjugated drugs released by low pH in endo/lysosome cause nucleus DNA damage and lead to apoptosis. This subcellular-targeted NIR-responsive nanomedicine with efficient integration of diagnosis and therapy, could significantly enhance cancer treatment by combination of chemotherapy and PTT.

Key words： chemotherapy photothermal therapy synergistic effect near-infrared

Published: Online: 2022-02-10

CLC number:

R730.53

Fund:National Natural Science Foundation of China (51803174).

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	TANG Zhaomin
	TIAN Weijun

Cite this article:

TANG Zhaomin,TIAN Weijun. Study on pH Responsive Nanomedicine in Chemo-photothermal Synergistic Therapy of Tumor[J]. Materials Reports, 2022, 36(3): 21120187-6.

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http://www.mater-rep.com/EN/10.11896/cldb.21120187 OR http://www.mater-rep.com/EN/Y2022/V36/I3/21120187

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