| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Nanomaterial-based Microneedle Arrays Technology and Its Application: a Review |
| LIU Yong, LIU Zhe, GAO Guangzhi, LI Zhiyong, MA Fengsen*
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| Laboratory of Biologics and Biomaterials, College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China |
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Abstract In recent years, microneedles have received a lot of attention from researchers because of its advantages of being painless and minimally invasive, safe and efficient. Microneedles have been widely used in the fields of transdermal drug delivery, medical aesthetics and biological diagnosis. However, traditional microneedles, especially those prepared directly from polymer materials, generally have problems such as low mechanical strength, single drug release mode, poor biological sensing performance and simple functions. The clever combination of nanotechnology and microneedles can effectively improve the above problems, due to the unique nano-size, mechanical strength and photoelectric effects of nanoparticles. This paper reviews nanoparticles for microneedles, including inorganic nanoparticles (metal, inorganic non-metal), organic nanoparticles (polymer, lipid) and drug nanoparticles (nanocrystalline drugs, virus-like particles), and describes the role of nanoparticles in increasing mechanical property, synergistic improvement of drug release and immune enhancement are introduced. Finally, the urgent problems need to be solved in this field and the future research directions are discussed.
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Published: 25 April 2023
Online: 2023-04-24
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| Fund:Key Science and Technology Innovation Team of Zhejiang Province (2013TD15). |
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2023, Vol. 37 
