| POLYMERS AND POLYMER MATRIX COMPOSITES |
|
|
|
|
|
| Preparation of pH Responsive Hydrogel Nanospheres Using Polyether Polyester Acrylate Crosslinkers and Their Application in Drug Release |
| ZONG Dan1, SHENG Yang1, LI Xinqing2, PAN Yan3, SUN Yixin1, DENG Linhong3, Mark Bradley4, ZHANG Rong1
|
1 School of Materials Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, China
2 Changzhou Second People's Hospital, Changzhou 213003, Jiangsu, China
3 Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, Jiangsu, China
4 School of Chemistry, University of Edinburgh, Scotland EH93 JJ, Edinburgh,UK |
|
|
|
|
Abstract Poly(ε-caprolactone-co-lactic acid)-PEG copolymer diols (PCLA) were prepared by ring opening polymerization of ε-caprolactone and L-lactide initiated by polyethylene glycol (Mw 1000). PCLA prepolymer monomers (PCLAMA) were prepared by end capping with methacrylic anhydride. The composition and structure of the synthesized products were characterized by FTIR, 1H-NMR and gel permeation chromatography. Hydrogel nanospheres(PCLAMA-AP)were prepared by UV initiated polymerization, using PCLAMA as a macromolecular cross-linker and N-vinylpyrrolidone and acrylic acid as monomers. Swelling, degradation, drug release and cytotoxicity of the hydrogel nanospheres were analyzed, and results show that the hydrogel nanospheres are pH-responsive and the swelling ratio of the hydrogel increases with pH increasing. The drug loading of tea polyphenol in the hydrogel nanospheres with the best monomer ratio is more than 57%, with cumulative drug release over 132 h reaching almost 30%. The hydrogel nanospheres are non-cytotoxic as evidenced by a cell viability of over 94% after co-culture with human adipose derived stem cells for 48 h, and are also observed to successfully enter the cells. The hydrogel nanospheres thus have potential to be used as drug carriers, which may greatly improve the bioavailability of tea polyphenols.
|
|
Published: 25 July 2022
Online: 2022-07-26
|
|
|
| Fund:‘Six Talent Peaks' Team Project in Jiangsu Province (SWYY-CXTD- 001), and International Cooperation Project Supported by Changzhou Science and Technology Bureau (CZ20190019). |
|
|
1 Hossen M S, Ali M Y, Jahurul M H A, et al. Pharmacological Reports, 2017, 69(6), 1194.
2 Buitimea-Cantúa N E, Gutiérrez-Uribe J A, Serna-Saldívar S O. Journal of Medicinal Food, 2018, 21(2), 188.
3 Gomes A, Oudot C, Macià A, et al. Nutrients, 2019, 11(11), 2634.
4 Zhang L, Chen X, Chen B, et al. Journal of Anhui Agricultural University, 2016, 43(5), 667(in Chinese).
张梁, 陈欣, 陈博, 等. 安徽农业大学学报, 2016, 43(5), 667.
5 Krook M A, Hagerman A E. Food Research International, 2012, 49(1), 112.
6 Uhrich K E, Cannizzaro S M, Langer R S, et al. Chemical Reviews-Columbus, 1999, 99(11), 3181.
7 Hamidi M, Azadi A, Rafiei P. Advanced Drug Delivery Reviews, 2008, 60(15), 1638.
8 Hu Y, Jiang X, Ding Y, et al. Biomaterials, 2003, 24(13), 2395.
9 Zeng Q, Qian Y, Huang Y, et al. Bioactive Materials,2021,6(9),2647.
10 Clasky A J, Watchorn J D, Chen P Z, et al. Acta Biomaterialia, 2021, 122, 1.
11 Woodruff M A, Hutmacher D W. Progress in Polymer Science, 2010, 35(10), 1217.
12 Ponjavic M, Nikolic M S, Nikodinovic-Runic J, et al. Polymer Testing, 2017, 57, 67.
13 Behtaj S, Karamali F, Masaeli E, et al. Biochemical Engineering Journal, 2021, 166, 107846.
14 Saini P, Arora M, Kumar M. Advanced Drug Delivery Reviews, 2016, 107, 47.
15 Basu A, Kunduru K R, Doppalapudi S, et al. Advanced Drug Delivery Reviews, 2016, 107,192.
16 Pauck R G, Reddy B D. Medical Engineering & Physics,2015,37(1),7.
17 Deng X, Zhou S, Li X, et al. Journal of Controlled Release, 2001, 71(2), 165.
18 Hu Y, Xie J, Tong Y W, et al. Journal of Controlled Release, 2007, 118(1), 7.
19 Zuk P A, Zhu M, Ashjian P, et al. Molecular Biology of the Cell, 2002, 13(12), 4279.
20 Zuk P A, Zhu M, Mizuno H, et al. Tissue Engineering,2001,7(2),211. |
|
|
|
渝公网安备50019002502923号 © Editorial Office of Materials Reports.
2022, Vol. 36 
