微小RNA纳米递送体系的构建及其研究进展

doi:10.11896/cldb.201901002

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Abstract MicroRNA (miRNA) is a class of small regulatory noncoding RNA (approximately 21—25 bases) endogenously expressed in animals, plants and pathogenic microorganisms. It has the function at the translation level as an important gene expression regulator. Until now, more than 1 000 miRNAs have been identified in organisms, which could regulate around 30% of human genes. MiRNA also plays a key role in cell growth, differentiation and apoptosis. More importantly, studies demonstrate that the expression of miRNAs in organisms is tightly associated with neurological disorders, cardiovascular diseases, cancer and viral infections. Therefore, miRNA has been widely used for early diagnosis, prognostic evaluation and therapeutic targets of many diseases. Regulating expression of miRNA by RNA interference technology in organisms has attracted more and more attention. By delivering miRNA or “antisense” nucleotides to cells, the expression level of target miRNA can be regulated, so as to achieve the treatment of diseases caused by gene disorders. Currently, miRNA-based therapeutics have shown great potential in cancer, emerging infectious diseases and other diseases. However, the characteristics of nucleotide chains, such as negativity and degradability, make it difficult for nucleotide chains to cross cell membranes into cells. Therefore, the rational design of delivery vectors is of great significance for improving the delivery and efficiency of therapeutic genes.
Until now, it has been reported that a variety of materials can be used as gene carriers for intracellular delivery of miRNA. Liposome capsules can enter the cell through endocytosis, which are prepared by encapsulating drug molecules in vesicles formed by phospholipid bilayer membranes. In addition, using the physical and chemical properties of different materials, various forms of nanocarriers, such as polymer nanoparticles, organic and inorganic nanoparticles, have been successfully developed and designed, which can achieve targeted delivery of gene drugs and intelligent stimulus release. In this review, we will discuss the function of intracellular miRNA and the methods of regulating the expression of miRNA, summarize the progress of nanocarriers in delivering miRNA therapeutic genes, and analyze the design ideas, methods and mechanisms of nanocarriers systems. In addition, according to the current research progress, we will discuss the development direction of miRNA-based therapy in emerging areas, in order to provide reference for the preparation of new intelligent gene delivery system.

Key words： Key words microRNA(miRNA) delivery system liposome polymer inorganic nanoparticle gene therapy

Published: 24 January 2019

CLC number:

TM914.4+2

Fund:This work was financially supported by the Fundamental Research Funds for the Central Universities (2017JQ010), the National Natural Science Foundation of China (61505076), the Natural Science Foundation of Guangdong Province (2017A030313299), Jiangsu Provincial Foundation for Distinguished Young Scholars (BK20170041), State Key Laboratory of Pulp and Paper Engineering (201706).

About author:: Jing Wei received her B.E. degree in applied chemistry from Jiangsu Normal University in 2017. She is currently pursuing her master’s degree in the Institute of Advanced Materials (IAM), Nanjing Tech University under the supervision of Prof. Changmin Yu. Her research focused on the functionalization of nanoparticles and their application for the miRNA delivery.Changmin Yu received his B.E. degree from Anhui University in 2008 and PhD degree from South China University of Technology in 2013. After that, he pursued postdoctoral studies in Chemistry at National University of Singapore in the years 2014 to 2015. He is currently a professor in Institute of Advanced Materials (IAM), Nanjing Tech University. Until now, he has published more than 40 SCI papers. His research interests include the functionalization of nanoparticles and their application in fluorescent detection, as well as in gene delivery.Wei Huang received his B.S., M.S., and Ph.D. degrees in Chemistry from Peking University in 1983, 1988, and 1992, respectively. In 2001, he became a chair professor at Fudan University, where he founded the Institute of Advanced Materials (IAM). In June 2006, he was appointed as the Deputy President of Nanjing University of Posts and Telecommunications. In July 2012, he was appointed as the President of Nanjing University of Technology. In June 2017, he was appointed as the Deputy President of Northwestern Polytechnical University. He is a member of the Chinese Academy of Sciences. His research interests include organic optoelectronics, nanomaterials, polymer chemistry, plastic electronics, and bioelectronics.

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	WEI Jing
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	ZHANG Chengwu
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	LI Lin
	YU Changmin
	HUANG Wei

Cite this article:

WEI Jing,HAN Xisi,ZHANG Chengwu, et al. Intracellular Delivery of MicroRNA Therapeutics Based on Nanocarriers: Current Status and Future Perspective[J]. Materials Reports, 2019, 33(1): 16-26.

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http://www.mater-rep.com/EN/10.11896/cldb.201901002 OR http://www.mater-rep.com/EN/Y2019/V33/I1/16

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