POLYMERS AND POLYMER MATRIX COMPOSITES |
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Progress in the Application of Bacteriorhodopsin in Biosensors |
LIU Wenqing1,2, ZHANG Tao1,3
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1 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083,China
2 University of Chinese Academy of Sciences, Beijing 100049, China
3 Shanghai Tech University, Shanghai 201210, China |
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Abstract Biosensor is a comprehensive integrated technology device that crosses multiple disciplines such as biological sensitive materials, physical and chemical transducers, and electrical signal amplification devices. Typical biosensors utilizebioactive materials with specific sensing functions as sensitive elements, combined physical and chemical transducers and conditioning circuits based on microelectronic devices, to rea-lize the conversion of biosensitive information into electrical signals and amplification. The sensitivity and anti-interference ability of transducers directly affect the performance of biosensor. Extracted from halobacterium salinarum, bacteriorhodopsin is a kind of biological material with good photosensitive properties. It can directly convert optical signals into electrical signals to realize the function of combining sensitive elements and transducers. It has been widely used in a variety of biosensors. The photosensitivity and stability of bacteriorhodopsin are suitable for the development of light sensors with color sensitivity, and the earliest application direction is artificial retina. The integration of photosensitivity and energy conversion characteristics can realize the function of optical motion detection using only a single sensor element, and the application can be extended to the field of motion sensing. In addition to its application in the area of vision sensing, bacteriorhodopsin has shown good sensitivity, stability and specificity in pathogen detection, water pH detection, cell membrane potential detection. It not only has application value in the field of biosensor, but also provides a new way for the research of semiconductor sensing methods. In this review, based on the brief introduction of the basic functions of bacteriorhodopsin, such as proton pump and photoelectric response cha-racteristics, the application progress of biosensor based on bacteriorhodopsin is described and the characteristics of different sensors are analyzed, so as to provide reference for the mechanism and application research of rhodopsin.
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Published: 10 December 2021
Online: 2021-12-23
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Fund:Knowledge Innovation Program of the Chinese Academy of Sciences |
Corresponding Authors:
haozzh@sina.com
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About author: Wenqing Liu received her bachelor's degree in agriculture from China Agricultural University in 2018. She is currently pursuing her Ph.D. at the Shanghai Institute of Technical Physics (SITP) Chinese Academy of Sciences under the supervision of researcher Tao Zhang. She majors in physical electronics. Her research has focused on perception and processing technology based on biological and photoelectric fusion. Tao Zhang received his bachelor's degree from Huazhong Institute of Technology (now Huazhong University of Science and Technology) in 1988 and received his Ph.D. degree from the Shanghai Institute of Technical Physics (SITP) Chinese Academy of Sciences in 2007. He is currently the director, researcher and doctoral supervisor of Group 1 at SITP, member of the expert group of National 863 Major Projects, member of the Science and Application Committee of Microgravity of Chinese Space Society, member of the 7th Council of Chinese Space Society. He had completed many research tasks including National 863 Program, National Manned Space Project and the important direction of the Chinese Aca-demy of Sciences Knowledge Innovation Project and so on, and proposed design method of modularization and module standardization of the space science experiment instrument. He was responsible for the development of a batch of new generation of space science experimental instrument prototype and key components, and achieved a number of research results. |
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