两性离子聚合物材料杀菌/抗黏附功能自适应转化的设计策略

doi:10.11896/cldb.20030130

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Abstract Zwitterionic polymers contain both anionic and cationic groups and exhibit strong hydration and good biocompatibility, which have been widely used in antifouling, drug carriers, sewage purification, anticoagulant materials and other fields. Self-adaptive materials based on zwitterionic polymers have become an important research direction for smart antibacterial area. The core design of smart zwitterionic polymers is introducing the responsive groups to their structure, rendering the transition between cationic state and the zwitterionic states under different external stimuli. Compared with the traditional antibacterial cationic polymers, the smart self-adaptive antibacterial zwitterionic polymers have the following advantages. First, self-adaptive zwitterionic polymers exhibit a good biological compatibility to normal tissue and cells under physiological conditions, automatically switch into a bactericidal state when bacteria infection occurs, and even the bactericidal state can be accordingly turned off. Second, zwitterionic polymer immobilizing on substrate can prevent the bacteria, protein and other contaminants from adhering to the surface, to avoid the reduction or even disappearance of the antibacterial functionality.
In this review, the progress of the antibacterial zwitterionic materials with self-adaptive transition is reviewed. The main approaches to design such smart antibacterial materials responding to exogenous and endogenous stimuli are described, the conversion mechanism between cationic and zwitterionic states is also discussed,and the applications of zwitterionic materials in antibacterial area are introduced. Furthermore, the future development of zwitterionic antibacterial materials are prospected.

Key words： cationic antibacterial polymer zwitterionic polymer stimuli responsive self-adaptive transition smart antibacterial materials

Published: 24 December 2020

CLC number:

O647.1

Fund:This work was funded by the National Key Research and Development Project (2017YFC1104800), National New Material Production and Application Demonstration Platform Project (TC90H3ZV), China Postdoctoral Science Foundation (2017M621225), Postdoctoral Innovation Project of Shandong ([2019]173), Postdoctoral Project of Weihai ([2018]45), and Chinese Academy of Sciences-Wego Group Hightech & Development Program.

About author:: Zhenlong Sun, Engineer of WEGO Holding Company Limited, and Manager of Public Affairs Department. His research has focused on medical polymer materials and medical devices. He has led the application and construction of more than 10 scientific research platforms above the provincial level, including National Engineering Laboratory of Medical Implantable Devices, High Performance Medical Device Innovation Center of Shandong Province, and High Performance Medical Device Innovation Center of Shandong Province.
Shunjie Yan, received his Ph. D. degree from University of Chinese Academy of Sciences in 2017. He currently serves as the Vice Director of Key Laboratory for Medical Implantable Devices of Shandong Province. His research interests are surface functionalization of biomedical materials and medical devices.

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	SUN Zhenlong
	ZHANG Zhenyan
	ZHOU Rongtao
	YAN Shunjie
	YIN Jinghua

Cite this article:

SUN Zhenlong,ZHANG Zhenyan,ZHOU Rongtao, et al. Strategies in the Design of Zwitterionic Polymer Materials with Self-adaptive Transition Between Bactericidal and Anti-adhesive Functions[J]. Materials Reports, 2020, 34(23): 23199-23204.

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http://www.mater-rep.com/EN/10.11896/cldb.20030130 OR http://www.mater-rep.com/EN/Y2020/V34/I23/23199

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