基于氧化-还原胺化反应改性海藻酸盐制备载药性电纺纳米复合纤维

doi:10.11896/cldb.19050027

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Abstract The amphiphilic alginate derivative (RAOA) was prepared via oxidative-reductive amination using the octylamine as a hydrophobic modifier. The structure and property of RAOA were characterized by FTIR,¹H NMR, fluorescence spectrum and optical contact angle measuring instrument. Furthermore, the electrospinning of hydrophobically modified alginate derivative, RAOA, was studied by using PVA as a spinning auxiliary. The physical properties of RAOA/PVA spinning solution and the morphology of corresponding RAOA/PVA electrospun composite nanofibers were determined by optical contact angle measuring instrument, electrical conductivity meter, rheometer and scanning electron microscopy. And the loading and release properties of the electrospun composite nanofibers for hydrophobic ibuprofen were also investigated. Experimental results showed that the octylamine had successfully grafted onto the alginate molecular chains. The critical aggregation concentration measured by fluorescence spectrum was reduced to 0.43 g/L, which demonstrated the good amphipathy of RAOA. The oxidation-reductive amination modification of RAOA could not fundamentally change the spinnability of a single RAOA solution, but it could enhance the content of RAOA in RAOA/PVA electrospun composite nanofibers. The drug-loaded SA/PVA electrospun composite nanofibers would release rapidly at the beginning, but RAOA can effectively retard the drug release rate of ibuprofen, thus improving the sustained release performance of RAOA/PVA electrospun composite nanofibers.

Key words： oxidation-reductive amination reaction alginate derivative electrospinning composite nanofibers sustained-release performance

Published: 29 May 2020

CLC number:

O648.2+3

Fund:This work was financially supported by the Natural Science Foundation of Hainan Province (219QN209), the Scientific Research Projects of Hainan Higher Education Institutions (Hnky2019-36), and the Innovation and Scientific Research Projects for Under-graduates of Hainan Normal University (cxcyxj2018004).

About author:: Huiqiong Yan received his B. E. degree from Hainan University in 2010 and Ph. D. degree from Hainan Normal University in 2017. He is currently an associate professor in College of chemistry and chemical engineering, Hainan Normal University. His research interests focus on the development and application of slow-release pesticide formulations, functional modification of seaweed polysaccharides, and preparation and application of tissue engineering scaffolds and biosensors based on alginate composite hydrogels. At present, he has published more than 60 journal papers, and applied for four national invention patents and three of them were authorized.

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	YAN Huiqiong
	ZHANG Wei
	WANG Yue
	HE Songming
	ZHAO Rui
	LIAO Yue
	CHEN Xiuqiong

Cite this article:

YAN Huiqiong,ZHANG Wei,WANG Yue, et al. Preparation of Drug-loaded Electrospun Composite Nanofibers Based on Oxidation-reductive Amination Reaction Modified Alginate[J]. Materials Reports, 2020, 34(12): 12139-12145.

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http://www.mater-rep.com/EN/10.11896/cldb.19050027 OR http://www.mater-rep.com/EN/Y2020/V34/I12/12139

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