碳羟基磷灰石纳米材料的研究进展

doi:10.11896/cldb.19040246

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Abstract Since the discovery of hydroxyapatite (HA), researchers all over the world started to explore its potential applications in many fields, especially in biological tissue materials, drug carriers, sewage treatments, and even in catalytic fields, but HA still has many shortcomings, especially in applications as biological tissue materials. Although HA is considered to be a good bone substitute, it is slightly different from bioapatite in terms of structure, crystallinity, solubility, composition, and bioavailability. In fact, most of the bioapatite contains a small amount of impurity ions and is weakly crystallized and non-stoichiometric. The main impurity ions are CO₃^2- and trace amounts of Na⁺, Mg²⁺, Fe³⁺, Cl^- and F^-. Among them, the role of CO₃^2- in bone metabolism is crucial, which accounts for about 3%—8% of the weight of calcified tissue, and can vary according to age factors. Furthermore, HA is the least soluble and most stable substance in calcium phosphate, which is highly disadvantageous as it could reduce the rate of bone regeneration during implantation. Therefore, the CO₃^2- substituted HA may have great potential applications in the fields of bone-related therapies.
Carbonated hydroxyapatite (CHA) is formed by the partial substitution of CO₃^2- ions in HA lattice. It is a special kind of isomorphism material to HA, and has many properties superior to HA. Firstly, because of the presence of CO₃^2- ion, the lattice structure of HA could be destroyed in a considerable extent, resulting in the development of special feature of solubility which is not exhibited by HA and it exhibits better bioresorbability. Secondly, the CHA can be produced by different methods of synthesis and annealed at various sintering temperatures, resulting in its formation with different morphologies and surface structures. These products have better biocompatibility, osteoconductivity, larger specific surface area and good mechanical properties. Presently, researchers have synthesized CHA with hollow and porous structure, with characteristic morphology of flower like cluster units or dandelion like structures. As the three dimensional morphology has larger specific surface area and internal space, its adsorption capacity and drug loading increases accordingly. At the same time, the porous structures could facilitate the continual release of drug and bone fusion.
In this review, the synthesis and characteristic properties of CHA are discussed. The effect of various preparation methods, their recent application and the development of CHA are reviewed. The challenges and future developmental prospects of CHA are briefly discussed. This article is expected to provide a reference for the preparation of other kinds of HA modified materials with better physiochemical properties.

Key words： carbonated hydroxyapatite nanomaterial bioactive materials porous materials

Published: 24 June 2020

CLC number:

TQ170

Fund:National Natural Science Foundation of China (21766016, 21566014, 51364023), Reserve Talents Program of Yunnan Province (2015HB014)

About author:: Jingyou Yuanreceived his B.E. degree in pharmaceutical engineering from Wuhan Huaxia University of Technology in 2018. He is currently pursuing his Master’s degree at the Faculty of Chemical Engineering, Kunming University of Science and Technology under the supervision of Prof. Qingming Jia and Prof. Shaoyun Shan. His research has focused on chemical environmental protection materials.
Shaoyun Shan is a professor and doctoral supervisor at the Faculty of Chemical Engineering of Kunming University of Science and Technology. At the same time, she is also a reserve talent for young and middle-aged academic and technical leaders in Yunnan Province, and the school head of mineral ecological environment functional ceramic materials. In recent years, her research interest is the field of chemical environmental protection, including a novel magnetic MIL-101(Fe)/TiO₂ composite, and CaO-based sorbent derived from lime mud and bauxite tailings for cyclic CO₂ capture.

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Cite this article:

YUAN Jingyou,JIA Qingming,SHAN Shaoyun. Recent Progress in the Field of Carbonated Hydroxyapatite Nanomaterials[J]. Materials Reports, 2020, 34(13): 13084-13090.

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http://www.mater-rep.com/EN/10.11896/cldb.19040246 OR http://www.mater-rep.com/EN/Y2020/V34/I13/13084

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