黑色素金属螯合物的研究进展及应用

doi:10.11896/cldb.19010197

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Abstract With the development and utilization of biomass resources, the development of melanin has aroused widespread interest among researchers. The inherent structure and function of natural melanin has been gradually developed into applications in biology, medicine and the environment. However, due to the structural characteristics and insoluble properties of its own high polymers, the development of melanin materials has been greatly hindered. Metal chelation is one of the important properties of melanin, and melanin provides multiple potential binding and biosorption sites for metal ions. The study of melanin metal chelate can better synergize the biological activity of melanin and metal ions, expand the application research of melanin and the design and development of metal matrix composites. Compared with melanin resources, melanin metal chelates have more specificity of biological activity and wide application.
The development of melanin metal chelate may depend on the different functional groups in the melanin structure, which can provide multiple non-equivalent binding sites for metal ions.These all simplify the preparation process of melanin metal chelate to a certain extent, and thus melanin can spontaneously covalently bond to metal ions by direct synthesis and step synthesis. However, its chelation effect is affected by pH, raw material ratio, time, temperature and metal ions, In order to further explore the formation of chelate structure, properties and the effect of metal ions on melanin structure, it can be analyzed by means of ultrastructural observation, molecular structure determination, metal binding amount and determination of binding sites.
At present, the research on melanin chelated metals has achieved initial success. Melanin has an adsorption effect on toxic elements such as mercury, lead, cadmium, chromium, molybdenum, uranium and thorium, and is expected to be used in the purification process of water; the exchange performance of melanin and metal ions has important biological significance in maintaining the homeostasis, oxidative stress and dynamic balance of metal ions; chelates formed by the action of melanin and dietary metals, magnetic metals and heavy metals have been applied to electrode materials, catalysts, imaging materials, color printing, photothermal therapy and other fields. In addition, the study of the interaction between melanin and metal ions is also crucial in determining the physical and structural properties of melanin and the properties of melanin metal chelates.
In this paper, the research progress of melanin chelated metals is summarized. The preparation, chelation mechanism and characterization of melanin metal chelate are introduced respectively.The application of melanin metal chelate in adsorbent materials, metal element supplements, electrode materials, catalysts and imaging materials is reviewed.The shortcomings of melanin metal chelate at present stage are analyzed and its prospects are expected. Provide reference for the development and research of metal-based functional materials and the comprehensive utilization of melanin.

Key words： melanin metal chelate chelation mechanism

Published: 13 May 2020

CLC number:

TS959.9

Fund:This work was supported by the Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi (201802075), the Key Research and Development Program of Shanxi Province (201803D221013-4, 201803D221026-4),Shanxi Province Key Laboratory of Functional Nanocomposites, North University of China (NFCM201603).

About author:: Yanling Ren graduated from Luliang College in June 2017 with a bachelor's degree in engineering. She is currently a graduate student at the Institute of Chemical Engineering and Technology of North University of China, under the guidance of Associate Professor Li Gao. Development and utilization of biomass resources in key research areas.
Li Gao is an associate professor at the Institute of Che-mical Engineering and Technology of North University of China and a master's tutor. In 2008, she obtained a doctorate degree in agronomy from Shanxi Agricultural University. In July 2008, she worked at North University of China. She is mainly engaged in research on high-value conversion and utilization of biomass resources and biocompatibility research in nanomaterials. Hosting and participating in the research project:the Key Research and Development Program of Shanxi Province; the Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi;Research on Structure and Performance of Nanomaterials. She has obtained and authorized 4 patents and published EI and SCI papers.

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	REN Yanling
	YANG Liu
	GAO Li
	WANG Fang
	SHI Nan
	ZHAO Yinghu
	GUO Lixiao
	WANG Haibin

Cite this article:

REN Yanling,YANG Liu,GAO Li, et al. Research Progress and Application of Melanin Metal Chelate[J]. Materials Reports, 2020, 34(11): 11145-11152.

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http://www.mater-rep.com/EN/10.11896/cldb.19010197 OR http://www.mater-rep.com/EN/Y2020/V34/I11/11145

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