基于动态可逆非共价体系的自愈合水凝胶构建方法研究进展

doi:10.11896/cldb.19010025

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Abstract The integrity of materials is a prerequisite for ensuring their performance. Any damage or defect may result in materials not meeting the requirements of application. For all kinds of materials, self-healing properties are strongly needed, especially for the hydrogels used as drug delivery carriers, tissue engineering scaffolds and functional device coatings because of their special application requirements. Developing self-healing hydrogels which can heal itself to maintain its initial performance after being damaged is vital to ensure the safety and reliability of materials in the use cycle, and thus has attracted more and more attentions.
　　In general, self-healing hydrogels can be divided into two types based on the forces between polymer chains. The first kind is formed by dynamic covalent bonds, including disulfide bonds, Diels-Alder cycloaddition reaction, imine bond/Schiff base interaction, etc. Others are formed by physically crosslinking of non-valent bonds like hydrogen bonds or van der Waals’ force, host-guest interaction, the interaction between polyelectrolyte, interaction of metal ligand, hydrophobic association, etc.
　　Due to the stability of covalent bonds, most hydrogels formed by covalent bonds are stable and can exhibit good mechanical properties. Howe-ver, these hydrogels have many limitations, including poor response to external stimuli, inability to be remodeled after being manufactured, and unable to heal themselves after being damaged. Thus, the development of self-healing hydrogels based on dynamic covalent or physical crosslinking has become a trend. Self-healing hydrogel not only exhibit high swelling ratio and water content, biocompatibility and biodegradability, but also has the ability to repair the fault, which can be used for tissue engineering, wound dressing, drug release and biosensing fields, prolonging the lifespan of materials and showing excellent application potential.
　　This review introduces the progress on the development of self-healing hydrogels based on dynamic reversible non-covalent system in recent years. The self-healing hydrogels are classified according to different healing mechanisms. The fabrication methods and application fields of self-healing hydrogels based on hydrogen bonding, reversible metal coordination, hydrophobic association and various interaction forces are reviewed respectively, and the problems and prospects of hydrogels based on dynamic reversible non-covalent system are discussed, aiming at providing ideas for the design, preparation and application of such hydrogels.

Key words： self-healing hydrogels hydrogen bonding metal coordination hydrophobic association biomedical engineering

Published: 16 January 2020

CLC number:

O63

About author:: Jueying Yangis a doctoral student at the School of Materials Science & Engineering, Beijing Institute of Technology. She is now engaging in the research of functional hydrogels based on natural polymers;Yu Chenreceived his Ph.D. degrees in Materials Science & Engineering from Beijing Institute of Technology in 2006. Now he is the associate professor and doctoral supervisor of School of Materials Science & Engineering, Beijing Institute of Technology. His study field including modification of the natural polymers and application of the corresponding materials in biomedical and environmental protection fields;Wei Yangreceived his Ph.D. degrees in Applied Chemistry from Beijing Institute of Technology in 2007. Now he is the assistant research fellow of School of Materials Science & Engineering, Beijing Institute of Technology. He is engaging in the study and project managing in the field of energetic materials and functional materials

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	YANG Jueying
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	ZHAO Lin
	ZHANG Zihan
	YANG Wei
	LIU Yuan
	PENG Kelin
	WANG Yalun

Cite this article:

YANG Jueying,CHEN Yu,ZHAO Lin, et al. Progress on Constructing of Self-healing Hydrogel Based on Dynamic Reversible Non-covalent System[J]. Materials Reports, 2020, 34(5): 5133-5141.

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http://www.mater-rep.com/EN/10.11896/cldb.19010025 OR http://www.mater-rep.com/EN/Y2020/V34/I5/5133

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